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《Journal of Molecular Diagnostics and Therapy》 2016-03
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Human heart-type fatty acid-binding protein,D-dimer and High-sensitive cardiac troponin T in the early diagnosis of acute coronary syndrome

PI Hongquan;LI Dehua;LUShengxiang;WANG Weihao;DENG Lehua;Department of Clinical Laboratory,Dongguan City Changping Hospital;Department of Cardiology,Dongguan City Changping Hospital;  
Objective To investigate the value of early diagnosis of human heart-type fatty acidbinding protein(h- FABP),D- dimerand high- sensitive cardiac troponin T(hs- c Tn T)in acute coronary syndrome(ACS). Methods All 157 blood samples of patients with chest pain in the emergency department of the Dongguan City Changping Hospital were selected. 50 healthy individuals were selected as the control group.h-FABP,D-dimer and hs-c Tn T were measured in all the specimens. All the experimental data were statistically processed by SPSS 13.0 statistical software. Results The levels of h-FABP,D-dimer,hs-c Tn T in the ACS group,which includes the unstable angina(UA)group,non-ST-elevation myocardial infarction(NSTEMI)group,and ST- elevation myocardial infarction(STEMI)group,were significantly higher than those of the non- ischemic chest pain(NICP)group and control group. There were significant differences between the ACS group and the NICP group and the control group(P=0.002). The levels of h-FABP in the ACS group between 3 to 6 h,were significantly higher than that of the controls(P=0.003). The levels of D-dimer and the hs-c Tn T in the group between 3 to 6 h were significantly higher than those of the controls(P=0.005). The sensitivity,specificity and accuracy was 87.07%,73.62% and 82.03% of the h-FABP in a separate diagnosis of ACS(chest pain for 3~6 h),but the sensitivity,specificity and accuracy were 97.41%,59.22%and 87.65% of the h-FABP,D-dimer and the hs-c Tn T with the affiliation diagnosis(Chest pain for 3~6 h).Conclusion The serum h-FABP is a more sensitive indicator of ACS in early myocardial ischemia than hs-c Tn T and plasma D-dimer. Serum h-FABP in combination with D-dimer and hs-c Tn T could improve sensitivity and accuracy,which are valuable to guide clinical diagnosis of ACS in early stages.
【CateGory Index】: R543.3
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