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《Journal of Molecular Diagnostics and Therapy》 2016-03
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Expression of regulatory T cells and interleukin-12 in aged patients with active pulmonary tuberculosis complicated with chronic bronchitis

XIAO Tianjin;ZHANG Leping;GU Zhongdong;HUANG Yanping;Department of Outpatient,Heyuan People's Hospital;Department of Outpatient,Shenzhen Center for Chronic Disease Control;  
Objective To investigate the expression of CD4~+CD25~+CD127~-regulatory Tregulatory cell(Treg) and interleukin-12(IL-12)in the aged pulmonary tuberculosis complicated with chronic bronchitis.Methods 80 cases of aged patients with active pulmonary tuberculosis complicated with chronic bronchitis were included in an observation group from January 2012 to December 2015 in the Peoples Hospital of Heyuan city. 80 cases with simple old chronic bronchitis and 80 healthy people from physical examination were chosen as the control group 1 and group 2, respectively. The levels of Treg cell(CD4~+CD25~+CD127-)ratio and peripheral blood IL-12 of the observation group were determined in 0,3 and 6 month intervals and compared with the control groups. Results IL-12 level of observation group was significantly lower than the control groups before treatment,the difference was statistically significant(P0.05),and CD4~+T cells ratio in the peripheral blood is lower than the control groups(P0.05),meanwhile the level of Treg cells is higher than the control groups(P0.05). Level of Treg cells decreased significantly and the expression of IL-12 increased after3,6 month treatment(P0.05). Conclusion Expression of Treg cells and IL- 12 is associated with the aged pulmonary tuberculosis complicated with chronic bronchitis,and can be used as a indicators of differential diagnosis and clinical outcome of the disease.
【CateGory Index】: R521;R562.21
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