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《Journal of Molecular Diagnostics and Therapy》 2016-03
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The mechanism of ERK1/2 kinases facilitate DNA damage response

WEI Fengxiang;ZHANG Lei;WANG Shaojuan;The Genetics Laboratory,Longgang District Maternity and Child Healthcare Hospital;Zunyi Medical University;Department of Obstetrics and Gynecology,Longgang District Renmin Hospital;  
The DNA damage response(DDR)helps to maintain genome integrity,and a critical event in this process is the prevention of cell division by activating the checkpoint until the DNA lesions can be repaired. The extracellular signal-regulated kinase(ERK)/mitogen-activated protein kinase(MAPK)pathway is a classic pathway for signal transduction and possesses multiple functions in regulating cellular proliferation,differentiation,and apoptosis. The functional connection between the DDR and ERK is the regulation of cell proliferation. This review aims to describe our current understanding of the function of ERK kinases in DDR.
【Fund】: 国家自然科学基金(81201568);; 深圳市海外高层次人才创新创业项目(KQCX20120814150420241);; 深圳市科技计划重点项目(201201009)
【CateGory Index】: R363
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