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《Journal of Molecular Diagnostics and Therapy》 2018-05
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The clinical and pathological characteristics of primary breast diffuse large B-cell lymphoma

WANG Yuanyuan;YANG Zhe;DENG Yuan;CHANG Hongyun;LI Xiaofeng;ZHANG Guanjun;LIU Xi;Department of Pathology,the First Affiliated Hospital of Xi'an Jiaotong University;  
Objective To investigate the clinicopathological characteristics and the genetic MYC gene rearrangement of primary breast diffuse large B-cell lymphoma(PB-DLBCL).Methods The retrospective analysis was performed for the clinical pathology data collected from 8 cases of PB-DLBCL who admitted to the First Affiliated Hospital of Xi'an Jiaotong University diagnosed with breast cancer or inflammation before surgery.The maximum diameter of the tumor ranges from 1.8 cm to 7.4 cm,with an average of 3.3 cm.There were 5 cases staged atⅠEA,2 at ⅡEA,and 1 at ⅣE. Immunophenotyping was performed by immunohistochemical staining. In situ hybridization was used to detect EBV infection status and MYC rearrangement.Results Tumor cells from PB-DLBCL were infiltrated into the breast tissues with a diffuse or slightly nodular pattern,and residual breast epithelium was present.The tumor cells were mediumlarge centroblastic-like or immunoblastic-like cytologic features. According to Hans classification,1 case was germinal center B-cell group(GCB)(12.5%),while 7 cases were non-GCB group(87.5%). EBER in situ hybridization was negative in 8 cases and no EBV infection.No MYC rearrangement or amplification were detected by in situ hybridization.Conclusions It is difficult to distinguish PB-DLBCL from breast cancer and inflammation only by clinical features. The accurate diagnosis depends on histopathology and immunophenotypic analysis.Most of PB-DLBCL are non-GCB group. Currently,no MYC rearrangement is found in PB-DLBCL.
【Fund】: 陕西省国际科技合作与交流计划项目(2016KW-001 2015KW-030);; 陕西省科学技术研究发展计划项目(2015SF128)
【CateGory Index】: R737.9
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