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《Journal of Molecular Diagnostics and Therapy》 2018-05
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The value of C-reactive protein,serum amylase A protein and neutrophil surface antigen CD64 in the early diagnosis of neonatal infectious diseases

WU Yuqin;KUI Liyue;ZHAO Xiaofen;LI Yangfang;CUI Shan;DU Kun;Special Hospital Ward,Kunming Children's Hospital;  
Objectives To investigate the value of C reactive protein(CRP),serum amyloid A(SAA)and neutrophils cell surface antigen 64(CD64)in the early diagnosis of neonatal infectious diseases.Methods 100 neonates were recruited in a neonatal ward who suspected of neonatal infection between May2016 and May 2017 in Kunming Children.s Hospital.20 hospitalized neonates with non-infectious diseases(such as neonatal respiratory distress syndrome, breast milk jaundice,gastrointestinal dysfunction,cephalohematoma)were enrolled as controls.CRP was detected by enzyme-linked immunosorbent assay,SAA was detected by Aopu gold digital quantitative analyzer and CD64 was detected by flow cytometry.The sensitivity and specificity of CRP,SAA and CD64 were analyzed in the early clinical diagnosis of neonatal infectious diseases. Results The levels of CRP,SAA and CD64 in the neonatal infectious diseases group were significantly higher than that in the control group(P0.01).The sensitivity and specificity of CD64 in the diagnosis of neonatal infectious disease are higher than that of SAA and CRP. Conclusion Both CRP and SAA can be used as criteria for judging neonatal infectious diseases. However,CD64 is a more sensitive early diagnostic indicator for neonatal infectious diseases.
【CateGory Index】: R722.1
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