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《Journal of Molecular Diagnostics and Therapy》 2018-05
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Analysis of the surveillance results of hand,foot and mouth disease in Yulin City in 2014-2017

TAN Lieming;DENG Yiyan;Yulin Red Cross hospital clinical laboratory,Guangxi;Yulin Red Cross hospital Paediatrics,Guangxi;  
Objective To analyze the incidence of hand-foot-mouth disease(HFMD)and its pathogen spectrum in Yilin city,and to provide a scientific basis for the diagnosis,treatment and prevention of HFMD.Methods A total of 32 077 anal swab specimens from patients with HFMD diagnosed in Yulin Red Cross Hospital from January 2014 to December 2017 were collected.The real-time fluorescence quantitativepolymerase chain reaction(q RT-PCR)technique was used to detect viral nucleic acid samples and analyze the virus type and clinical relevance. Results The positive rate of enterovirus was 80.1%(25 870/32 077). The positive detection rates of EV71,CA16 and non-EV71/CA16 were 12.4%(3 203/25 870),5.4%(1 402/25 870)and 82.2%(21 265/25 870),respectively.Non-EV71/CA16 type was the main type. There was a significant difference between non-EV71/CA16 group and CA16 or EV71(P0.01).The positive rate between male and female was not statistically significant difference(P0.05).The incidence of HFMD has obvious seasonality of HFMD and the number of cases is mainly concentrated from April to September. Conclusion The pathogen spectrum of HFMD in Yulin city has changed in 2014-2017,and the non-EV71/CA16 enterovirus became the dominant strain. Therefore,the monitoring of untyped samples should be strengthened. More attention should be paid to the diagnosis,treatment,daily monitoring and prevention and control of HFMD.
【CateGory Index】: R725.1
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