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《Journal of Molecular Diagnostics and Therapy》 2018-05
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Correlation between serum LDL and peripheral neuropathy in type 2 diabetes

HUANG Juan;HU Wei;XIONG Dan;Department of Endocrinology,the First Affiliated Hospital of Hunan University of Chinese Medicine;  
Objective To investigate the correlation between serum low density lipoprotein(LDL)and diabetic peripheral neuropathy(DPN)in type 2 diabetes mellitus. Methods A total of 166 patients with type 2 diabetes mellitus(T2 DM)who were treated in the First Affiliated Hospital of Hunan University of Chinese Medicine from April 2016 to March 2017 were enrolled. Among them,94 patients with T2 DM had no peripheral neuropathy and were included in the non-DPN group,while peripheral neuropathy in72 patients with T2 DM was included in the DPN group. Serum LDL levels and related clinical biochemical parameters were measured in the 2 groups.Results The age,duration of diabetes,hemoglobin A1 c(Hb A1 c),malondialdehyde(MDA)and LDL levels were significantly higher in the DPN group than in the non-DPN group(P0.05). The fasting C-peptide level in the DPN group was significantly lower than that in the non-DPN group(P0.05).There was no difference between non DPN and DPN groups of the gender,body mass index(BMI),blood calcium concentration,blood phosphorus concentration,urea nitrogen(BUN),serum creatinine(Scr),systolic blood pressure(SBP)and diastolic blood pressure(DBP)(P 0.05). Pearson correlation analysis showed that serum LDL levels were positively correlated with diabetes course,Hb Alc,BMI and BUN(P0.05),and negatively correlated with serum calcium levels,serum phosphorus levels,Scr levels,and fasting C-peptide(P0.05)and not related to the patient.s age,SBP or DBP(P0.05).Using DPN as the dependent variable and the patient.s serum LDL,diabetes course,Hb Alc,BMI,BUN,blood calcium level,blood phosphorus level,Scr level and fasting C peptide as the independent variables,multivariate logistic stepwise regression analysis indicated that LDL and Hb A1 c were positively correlated with DPN,and fasting C peptide was negatively correlated with DPN.Conclusion This study demonstrated that LDL and Hb A1 c are related factors for the type 2 diabetic peripheral neuropathy. Serum LDL level is closely related to the glucose and lipid metabolism index and biochemical indicators of patients,and it has an important clinical significance.
【CateGory Index】: R587.2
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