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《China Medical Equipment》 2015-01
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Effect of three-dimensional conformal radiotherapy versus dose boosted with gamma ray stereotactic body radiotherapy on locally advanced pancreatic cancer

HU bin;HOU Yan-li;MA Xiu-mei;Department of Radiation Oncology,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University;  
Objective: To analyze retrospectively the different efficacy between linear accelerator X-ray with three-dimensional conformal radiotherapy(3D-CRT) and dose boosted with gamma ray stereotactic body radiotherapy(SBRT) for locally advanced pancreatic cancer patients. Methods: A total of 61 patients with locally advanced pancreatic cancer were enrolled. All the patients were first performed by 3D-CRT, the volumes of irradiation included the pancreatic tumor(GTV) and the draining lymph node region, total scheduled dose was 40 Gy in 20 fractions. Then boosted the dose to GTV, 21 cases with 3D-CRT(3D-CRT group), total dose of 46Gy;40 cases with SBRT(SBRT group), total dose of 56 Gy. Results: The median survival time was 11.3 months for all cases. Patients with pretreatment KPS ≥90, combined with chemotherapy and femal had better prognosis. The corresponding MSTs were 14.1 months vs 9.2 months(x2=8.992, P=0.003),13.0 months vs 9.6 months(x2=4.056, P=0.044) and 12.5 months vs 10.7 months(x2=3.953, P=0.047) respectively. The median survival time of 3D-CRT group and SBRT group were 7.5 months and 13 months, P0.05. There were no statistic differences between 2 groups in terms of side effects induced by treatments. Conclusion: The gamma ray stereotactic body radiotherapy is effective and safe and has the trend to improve the survival rate for patients with locally advanced pancreatic cancer. Patients with better performance status before treatment, combined with chemotherapy and female may have better prognosis.
【CateGory Index】: R735.9
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