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《China Medical Equipment》 2015-01
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Research on effect of tirofiban on patients with ST-segment elevation acute coronary syndrome undergoing intervention treatment

DU Rui;The People’s Hospital of Dujiangyan City;  
Objective: To analyze the effect of tirofiban on patients with ST-segment elevation acute coronary syndrome undergoing intervention treatment. Methods: Chosen patients with ST-segment elevation acute coronary syndrome between November 2012 to November 2013 as research subjects,randomly assigned to observed group received conventional treatment and control group received tirofiban perioperative, detecting before and after platelet CD40 L expression, serum CRP levels, cardiovascular events. Results: 1)After treatment, observed group patients platelet CD40 L expression intensity was significantly lower than control group(t=3.281, P0.05);2) at various time points after dosing, serum CRP in observation group were significantly lower than control group patients(t=2.183, t=2.748, t=4.719; P0.05); 3)After treatment, observation group patients cardiovascular event rate was significantly lower than control group(x2=6.493, P0.05). Conclusion: Perioperative tirofiban therapy can effectively reduce the expression and inflammation in patients with platelet levels, reduce the incidence of adverse cardiovascular events, with positive clinical significance.
【CateGory Index】: R541.4
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Shu-qing,SONG Bing-hui, LIU Yuan-zhi,JIA Shan-shan, XIE Guang-yu (a.Department of Circulation;b.Department of Endocrine;c.Department of Gastroenterology,First Hospital of Qiqihar City,Qiqihar 161005,Heilongjiang Province,China);Reasonable application of tirofiban in patients with acute coronary syndrome and risk factors analysis[J];The Chinese Journal of Clinical Pharmacology;2012-10
2 LIU Tao,XIE Ying,ZHOU Yu-jie,MA Han-Ying,GUO Yong-he,LI Yue-ping,CHENG Wan-jun,LIU Yu-yang,ZHAO Ying-xin,SHI Dong-mei.Department of Cardiology for Elders,Beijing Anzhen Hospital,Capital University of Medical Science,Beijing 100029,China;Effects of upstream versus downstream administration of tirofiban on short-term prognosis in patients with high-risk acute coronary syndromes[J];Medical Journal of Chinese People's Liberation Army;2009-02
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 LUO Shi-tang(Department of Cardiology,the Third Affiliated Hospital of Guangdong Medical College,Maoming 525000,China);Application of Tirofiban in Treatment of Acute Myocardial Infarction with Facilitated PCI[J];Practical Clinical Medicine;2013-06
2 LEI Li-cheng;PENG Jian-jun;YANG Nuo;WANG Zuo-yan;YE Hui-ming;GUAN Fu;YANG Shui-xiang;Department of Cardiology,Beijing Shijitan Hospital,Capital Medical University;;Application of low-dose tirofiban in emergent intervention for patients with high CRUSADE score in acute ST segment elevation myocardial infarction[J];Medical Journal of Chinese People's Liberation Army;2014-06
3 ZHANG Su;YAO Bin;Teaching and Research Department of Biochemistry and Exercise Physiology,Shenyang Sport University;Department of Rehabilitation,Jinqiu Hospital in Liaoning Province;;Clinical study of tirofiban in treatment of high-risk non-ST elevation acute coronary syndrome around perioperative period intervention[J];;2014-03
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