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《Medical Recapitulate》 2006-01
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Role of Neutrophil Elastase in the Repair of Lung Tissue Injury

TAN Shan-zhong,LIU Cheng-hai.(Liver Disease Institute,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)  
Neutrophil elastase is one of the most predominant neutral proteinase of proteinases in neutrophilic lysosome,It is possible to hydrolyze peri-bronchial tissue,injury bronchial cilia and epithelial cells,degrade elastin,and destroy structure of pulmonary alveolus.The neutrophilic elastase plays a important role in acute lung injury,bronchiectasis,emphysema and pulmonary fibrosis.In this review,the actions and mechanism of neutrophil elastase in the repairing lung injury were summarized.
【Fund】: 上海市科学技术委员会重点基础研究项目(04JC140069);; 上海高校中医内科学E-研究院建设计划(E03008);; 上海市教育委员会重点学科建设部分资助
【CateGory Index】: R563
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