Relationship between Proteinase-activated Receptors and Bronchial Asthma
LI Liang.(Naval General Hospital of PLA,Beijing 100037,China)
Proteinase-activated receptors(PARs)are belong to the category of G protein-coupled receptors.By far,there are two relatively clear defined members in this great family,namely,Proteinase-activated receptor-1(PAR-1)and Proteinase-activated receptor-2(PAR-2).Two receptors are widely seen in various tissues and cells,such as endothelial cells,T lymphocytes,and smooth muscle cells,etc.A series of reactions caused by signal transmitting mechanism mediated by the activations of PAR-1 and PAR-2 which they are activated by thrombin and tryptase,respectively,play a pivotal role in pathogenic mechanism of asthma,It also have the potential of providing a new method for asthma.
【CateGory Index】： R562.25