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《Medical Recapitulate》 2006-09
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Signal Transduction of Fas and Pulmonary Interstitial Fibrosis

ZHANG Zheng-shou,JIANG Han-dong.(Department of Respiratory Medicine,the Affiliated Hospital of Medical College,Qingdao University,Qingdao 266003,China)  
Fas antigen(Fas)is a type Ⅰ membrane protein belonging to the tumor necrosis factor receptor(TNFR)/nerve growth factor receptor(NGFR)super family.Cross-linking of Fas with its ligand,FasL,or its competitive antibody can induce cell apoptosis.The signal transduction and regulatory mechanisms of Fas plays an important role in keeping self balance in organism and the development of many deseases.It has also been proved that Fas signaling plays a critical role in pulmonary interstitial fibrosis in recent years.The recognition of this mechanism may provide a new method in the therapy of current -pulmonary interstitial fibrosis.
【CateGory Index】: R563.9
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Chinese Journal Full-text Database 2 Hits
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