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《Medical Recapitulate》 2006-12
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Onset Characteristics of NOD Mice With Type-1 Diabetes

ZHANG Li-bo,XIA Ning,LIANG Yu-zhen.(The Center of Metabolic And Diabetes Mellitus,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)  
Type-1 diabetes is the result of autoimmune destruction of insulin-secreting pancreatic β cells,which leads to insulin absolutely deficiency and hyperglycemia.There is still no radicle cure method for that.Nonobese diabetic(NOD) mice spontaneously develop type-1 diabetes and are considered to be one of the best animal models for human insulin-dependent diabetes mellitus.The mice of this strain have an unusual H-2 g7haplotype (Kd、I-A g7、I-E null、Db),show Insulitis and progressive destroy of beta cell of islet at 4~5 weeks of age and exhibit diabetic symptoms at 12 weeks of age.The cumulative incidence of the onset up to 30 weeks of age is 80% in females,but less than 20% in males.
【CateGory Index】: R587.1
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【References】
Chinese Journal Full-text Database 2 Hits
1 ZHAO Yan1 GAO Feng1 LV Ping2(1Department of Endocrinology,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430022,China;2Department of Vascular Surgery, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology);Isolation and purification of Sca-1~+ cell from nonobese diabetic (NOD ) mice[J];Journal of Clinical Hematology;2009-01
2 HU Ning-zhu,WANG Hai-xuan,HU Yun-zhang(Institute of Medical Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Kunming 650118,China);Diabetes 1 Antisense Peptide Phage Vaccine Induces Inhibitory Effect of CD8~+ T Cells on Pathologic CD4~+ T Cells[J];Chinese Journal of Biologicals;2009-08
【Citations】
Chinese Journal Full-text Database 1 Hits
1 SHI Mei-lian,ZHU Dong-qin,GAO Jing-hua,BAO Shi-ming,XU Ping,ZHANG Ying,ZHANG Ai-fang(National Laboratory Animal Center of Rodents,Shanghai Branch,Shanghai 201615;Shanghai Laboratory Animal Center,Chinese Academy of Science,Shanghai 201615;Research section;Genetic and some biological characteristics of NOD mice[J];Journal of Shanghai Jiaotong University (Agricultural Science);2002-03
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 CHAI Xiang-hai,JIN Xian-long(School of Mechanical Engineering,Shanghai Jiaotong University,Shanghai 200240,China);The 3D Simulation Modeling and Application of Paroxysmal Calamity in Public Places Based on Agent[J];Journal of Shanghai Jiaotong University;2008-10
2 HU Bin-ya,REN Ji-hao,LU Yong-de,et al.(Department of Otorhinolaryngology,Hunan Children's Hospital,Changsha 410007,China);Expression of Bcl-2 and Bax in cochlea of mice with spontaneus diabetic[J];Chinese Journal of Otorhinolaryngology-Skull Base Surgery;2010-04
3 FENG Hao,GUO Bao-Yu,ZHANG Shu-Ying.Department of Biochemical Pharmacy,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;The establishment of adoptive transfer model of type 1 diabetes in NOD.Scid mice[J];Chinese Journal of Immunology;2005-08
4 Zou Xiaolei,Cao Yu.Yuan Siyou,Xiang Ming Department of Pharmacology, College of pharmacy, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430030, P. R. China;Type 1 Diabetes Induced by Adoptive Transfer of Diabetogenic T Cells and Mechanism Research[J];China Pharmacist;2006-10
China Proceedings of conference Full-text Database 1 Hits
1 ;1.25(OH)_2D_3对NOD小鼠心肌超微结构的影响[A];[C];2009
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 PENG Fang,YANG Yuan-hua (Department of Pharmacology,Dali college,Dali671000China);Evaluation of Measuring Indexes and Establishing Models about Experimental Diabetics[J];Journal of Dali College;2003-01
2 XIN Xiao lin (Department of Biology,yantai Normal University,yantai 264025,China);The Effect of Rats' Liver Index And MDA Content Made By Auoxan[J];Journal of Qinghai Normal University(Natural Science Edition);2001-01
3 CHEN Qiu, XIA Yongpeng, QIU ZongyinDepartment of Pharmacology, Chongqing Medical University, Chongqing 400016,China;Establishment and Evaluation of Rat Models of Type 2 Diabetes Mellitus[J];Tianjin Medical Journal;2006-01
4 SHI Lin, YUAN Yu-kang, SHENG Li, FAN Gui-xiang~ * Department of Immunology and Microbiology, Medical School of Xi’an Jiaotong University, Xi’an 710061, China;Inducement of cytotoxic T cell responses in mice by constructing a multi-CTL epitope-based DNA vaccine[J];Chinese Journal of Cellular and Molecular Immunology;2006-04
5 Gao Hong-li,Liu Fang-yong,Xia Zuo-li Gao Hong-li1,Liu Fang-yong2,Xia Zuo-li3,1Department of Traditional Chinese Nursing,School of Nursing,2Department of Postgraduate,3 Institute of Basic Medicine,Taishan Medical College,Taian 271000,Shandong Province,China;Theoretical study and application of experimental diabetic animal models[J];Chinese Journal of Clinical Rehabilitation;2005-03
6 AI Jing1,WANG Ning1,DU Jie1,YANG Mei1,LIU Ping1,DU Zhi-min2,YANG Ba o-feng1 (1.Dept of Pharmacology, Bio-pharmceutical Key Laboratory of Heilongjiang Pr ovince; 2.State Base for Drug Clinical Trial, Harbin Medical University, Harbin 150086,China);Establishment of type 2 diabetic animal model in Wistar rats[J];Chinese Pharmacological Bulletin;2004-11
7 J Liu,ZF Shen,HF Liu,F Ye and MZ Xie(Institute of Materia Medica ,Chinese Academy of Medical Sciences, Peking Umion Medical College,Beijing100050);AN ANIMAL MODEL FOR TESTING HYPOGLYEMIC AND HYPOLIPIDEMIC DRUGS[J];ACTA PHARMACEUTICA SINICA;1994-05
8 CAO Wei 1, WEI Ya hui 2, YANG Jian xiong 1(1. College of Life Science, Shanxi Normal University, Xi'an Shanxi 710062, China; 2. College of Life Science, North West University, Xi'an Shanxi 710069, China);Protective effect of propolis extract on activity oxygen free radical and alloxan-induced hepatic injury in rat[J];Chinese Traditional and Herbal Drugs;2001-11
9 ZHANG Fanglin, LI Guo, LIU Youping, DING Wei, YIN Jun, XU Guangwu, ZHANG Di, ZHOU Wenzhong, LUO Min (Shanghai Institute of Endrocrinology,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China);Rat Model of Type 2 Diabetic Mellitus and Its Glycometabolism Characters[J];Acta Laboratorium Animalis Scientia Sinica;2002-01
10 LIU Zhao-Xia,TIAN Ze-Wei,DONG Wen-Qi,WANG Ping.Department of Medical Laboratory,College of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510315,China;Study of the immune responses induced with the chimeric HBc gene vaccine carrying the compound multiepitopes gene of HBV in BALB/c mice[J];Chinese Journal of Immunology;2006-07
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