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《Medical Recapitulate》 2006-12
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Onset Characteristics of NOD Mice With Type-1 Diabetes

ZHANG Li-bo,XIA Ning,LIANG Yu-zhen.(The Center of Metabolic And Diabetes Mellitus,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)  
Type-1 diabetes is the result of autoimmune destruction of insulin-secreting pancreatic β cells,which leads to insulin absolutely deficiency and hyperglycemia.There is still no radicle cure method for that.Nonobese diabetic(NOD) mice spontaneously develop type-1 diabetes and are considered to be one of the best animal models for human insulin-dependent diabetes mellitus.The mice of this strain have an unusual H-2 g7haplotype (Kd、I-A g7、I-E null、Db),show Insulitis and progressive destroy of beta cell of islet at 4~5 weeks of age and exhibit diabetic symptoms at 12 weeks of age.The cumulative incidence of the onset up to 30 weeks of age is 80% in females,but less than 20% in males.
【CateGory Index】: R587.1
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