The Significance about Intervention of Aldosterone′s Escape in Cardiovascular Diseases
ZHANG Li-ming,LIU Xin-lin,SHI Ru-hai.(The 535 Hospital of PLA,Huaihua 418008,China)
The phenomenon of aldosterone escape means that its serum level will decrease in short time and then increase in long time during the application of ACEI.Its synthesis and releasing is also increased in chronic heart failure.Sodium retention,electrolyte disturbances,lipid collage deposition and fibrosis will result in progressive aggravation of chronic heart failure.Chemical constitution of aldoctone is similar to that of aldosterone which can inhibit its effect,decrease the total case fatality and /or length of stay of the heart failure and inhibit arrhythmia.The new selective adosterone antagonists can be a high recommended indication medicine in heart failure,hypertension and post-infarction of myocardium.
【CateGory Index】： R54