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Study Progress of Malignant Tumor Imaging of Integrin αvβ3 Expression with Radiolabelled RGD Peptides

LIU Kai-yuan,LI Qian-wei,LIU Guang-yuan.(Center of Nuclear Medcine,Southwest Hospital,The Third Military Medical University,Chongqing 400038,China)  
The malignant tumors must establish a neovasculature to grow,to invade,and to metastasize,in which integrinsαvβ3 play an important role.It is found that the αvβ3 integrins produced its effect mainly by binding to triplet peptides RGD sequence in the proteins of the extracellular matrix.Because the expression of αvβ3 integrins is reported to be strong on activated endothelial cells but absent or rare on normal cells,so radiolabeled RGD antagonistic peptides could be used as high tumor specific markers to display tumor by nuclear medicine image and then we can success in early diagnosis and therapy.This article reviews the marking method of RGD peptide and study about the image ofαvβ3 receptor.
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