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《Medical Recapitulate》 2006-12
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Study Progress of Malignant Tumor Imaging of Integrin αvβ3 Expression with Radiolabelled RGD Peptides

LIU Kai-yuan,LI Qian-wei,LIU Guang-yuan.(Center of Nuclear Medcine,Southwest Hospital,The Third Military Medical University,Chongqing 400038,China)  
The malignant tumors must establish a neovasculature to grow,to invade,and to metastasize,in which integrinsαvβ3 play an important role.It is found that the αvβ3 integrins produced its effect mainly by binding to triplet peptides RGD sequence in the proteins of the extracellular matrix.Because the expression of αvβ3 integrins is reported to be strong on activated endothelial cells but absent or rare on normal cells,so radiolabeled RGD antagonistic peptides could be used as high tumor specific markers to display tumor by nuclear medicine image and then we can success in early diagnosis and therapy.This article reviews the marking method of RGD peptide and study about the image ofαvβ3 receptor.
【CateGory Index】: R730.44
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1 Hao Yumei;He Xin;Song Naling;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences,Peking Union Medical College;;Progress on tumor angiogenesis imaging targeting integrin αvβ3 receptor[J];国际放射医学核医学杂志;2014-03
【Citations】
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1 LI Qian wei,ZHENG Xiu hai,ZHANG Guang yun,WANG Shu guang (Nuclear Medicine Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Scintigraphy of tumor α_vβ_3 receptor with ~(125)I-RGD-4CY in nude mice[J];第三军医大学学报;2002-11
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ;The antitumor mechanism and progress of RGD peptide[J];吉林医药学院学报;2015-05
2 MA Jian-rong1,YU Yong-hong1,ZHANG Jing-hai2(1,Center for Practice and Training,Guangdong Food and Drug Vocational College,Guangzhou 510520; 2,School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China);Expression vector of a lung targeted fusion protein AGAP in Pichia pastoris,construction of plasmid pPIC9K-RGD-4C-His Tag-AGAP[J];生物学杂志;2011-05
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【Co-references】
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1 Yumei HAO;Xin HE;Xiaoliang ZHOU;Aimin MENG;Jianfeng LIU;Jinjian LIU;Naling SONG;Department of Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College,Chinese Academy of Medical Sciences;;Radio-labeling of T7 Peptide with ~(99m)Tc and Its Biodistribution in Nude Mice Bearing Non-small Cell Lung Cancer[J];中国肺癌杂志;2014-03
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5 LIU Kai-yuan,LI Qian-wei,LIU Guang-yuan.(Center of Nuclear Medcine,Southwest Hospital,The Third Military Medical University,Chongqing 400038,China);Study Progress of Malignant Tumor Imaging of Integrin αvβ3 Expression with Radiolabelled RGD Peptides[J];医学综述;2006-12
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