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Progress of Panax notoginseng in Pharmacological and Clinical Research for Nephropathy

ZHANG Heng-yuan1,JIN Jian-sheng2.(1.Institute of Clinical Immunology,Union Hospital Affiliated to FuJian Medical University,Fuzhou 350001,China; 2.Department of Nephrology,The First Hospital in Xiamen Affiliated to FuJian Medical University,Xiamen 361003,China)  
Panax notoginseng has various biological functions.It may prevent the progression of renal interstitial fibrosis through the effect on renal tubular epithelial cells and kidney fibroblasts.Its pharmacological mechanism also includes immunoregulation;influence on the expression of inflammatory factors;elimination of oxygen free radicals;inhibition of calcium uptake;influence on substance metabolism,improvement of blood microcirculation and so on.Panax notoginseng was applied in clinic to treat kidney diseases such as chronic glomerulonephritis,nephrotic syndrome,diabetic nephropathy,chronic renal failure,in which it got a significant curative effect.The further study in the pharmacological and clinical research of Panax notoginseng would provide a new way of prevention and treatment for kidney diseases.
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