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《Medical Recapitulate》 2006-24
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Diagnositic and Therapeutic Progress of Late-onset Autoimmune Diabetes in Adults

ZHENG Hua,XIA Ning,LIANG Yu-zhen.(The Center of Metabolic and Diabetes Mellitus,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)  
Late-onset autoimmune diabetes in adults (LADA),presenting with a similar phenotype of type 2 diabetes at early stage,belongs to the slowly progressive subtype of autoimmune type 1 diabetes.The difference between LADA and classic juvenile-onset type 1 diabetes is that its autoimmune destructive process of islet beta- cells is much slower.LADA may serve as a human model of autoimmune type 1 diabetes.Although no international standardized criteria for the diagnosis of LADA has been established,it should be noted that the diagnosis of LADA shuould be based on many aspects including clinical characteristics,susceptible genotypes,cellular and humoral immune markers,as well as islet pathology,in which autoantibody of islets is the important index in diagnosing LADA.Studying the pathological changes wil be helpful to know the immune destructive process of βcells as well as provide the basis for the prevention or even cure of type 1 diabetes.
【Fund】: 2005年广西科技攻关课题(桂科能05112001-4A)
【CateGory Index】: R587.1
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Xia, ZHOU Zhi guang, HUANG Gan, et al. Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China;Rosiglitazone combined with insulin preserves islet β cell function in LADA:A preliminary study[J];中国糖尿病杂志;2003-04
2 YANG Lin *, ZHOU Zhi guang, HUANG Gan, et al. *Institute of Metabolism and Endocrinology, Xiangya 2nd Hospital, Central South University, Changsha 410011, China;Carboxypeptidase-H antibody assay for the diagnosis of latent autoimmune diabetes in adults[J];中国糖尿病杂志;2003-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Li-jun,ZHANG Jian-jun,OU Yan-juan,ZHANG Tao,PANG Wu-yan,XU Ji-xiang(Huaihe Hospital of Henan University,Henan Kaifeng 475000,China);Effects of Xiaokang Pills Combined with Insulin on the Function of Pancreatic Islet B Cells in Patients with Latent Autoimmune Diabetes Mellitus[J];中国药房;2013-16
2 SUN Sheng-hua*,SONG Qin-hua,LIU Hai-wei,Chen Jin-yi,WANG Zhuan-suo. *Department of Endocrinology and Metabolism,the Affiliated Hospital of Hainan Medical College,Haikou,Hainan 570102,China;Effect of the Pioglitazone on beta cell of islet of the LADA patients[J];现代预防医学;2012-06
3 GUO Xiao-hui.Department of Endocrinology,The First Hospital,Beijing University,Beijing 100034,China;Progress in the protective action of liraglutide on the islet β cells[J];中华内分泌代谢杂志;2011-10
4 YANG Lin,ZHOU Zhiguang,DU Tao,TAN Shaozhen,ZHNAG Yi,JIN Ping(Department of Endocrinology,Institute of Metabolism and Endocrinology,Diabetes Center,Second Xiangya Hospital,Central South University,Changsha 410011,China);Detection of carboxypeptidase H specific T cells in peripheral blood of latent autoimmune diabetic patients with carboxypeptidase antibody positivity by ELISPOT assay[J];中南大学学报(医学版);2009-10
5 XIE Hong-fen1,NI Hong2,CHEN Zhong-yu3.1.The Third People's Hospital of Chengdu,Chengdu,Sichuan 610031;2.Chengdu Raiway Branch Hospital,Chengdu,Sichuan 610081;3.The First People's Hospital of Chongqing,Chongqing 400001,China;The significance of investigation of three islet autoantibodies in latent autoimmune diabetes in adults(LADA)[J];四川医学;2009-03
6 XU Xiao-wei and ZHANG De-xian Department of Endocrinology and Diabetes Mellitus,Qingdao Hiser Medical Center,Shandong(266033);Effect of Tangyikang in Improving the Function of Pancreatic Islet β Cells in Patients with Latent Autoimmune Diabetes Mellitus in Adults[J];中国中西医结合杂志;2008-10
7 YANG Lin, ZHOU Zhi-guang, HUANG Gan, JIN Ping, QI Hai-ying (Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China);Cross-sectional study of the relation between carboxypeptidase-H antibody and islet β cell function in patients with latent autoimmune diabetes in adults[J];中南大学学报(医学版);2006-06
8 ZHENG Hua,XIA Ning,LIANG Yu-zhen.(The Center of Metabolic and Diabetes Mellitus,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China);Diagnositic and Therapeutic Progress of Late-onset Autoimmune Diabetes in Adults[J];医学综述;2006-24
9 Chai Jie,Wang Ke,Jia Aiqin.Department of Endocrinology,Second People′s Hospital of Shenzhen (Shenzhen 518029,China);Clinical analysis of 24 cases of late autoimmune diabetes in adults.[J];中国医药;2006-05
10 YANG Lin, ZHOU Zhi-guang, HUANG Gan, JIN Ping, QI Hai-ying, Li Xia, CHEN Xiao-yan. Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011;The efficacy of 4 islet autoantibodies in the diagnosis of latent autoimmune diabetes in adults[J];中华内分泌代谢杂志;2005-04
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Xia, ZHOU Zhi guang, HUANG Gan, YAN Xiang, YANG Lin, HU Bai ying Department of Endocrinology, Xiang Ya Second Hospital, Central South University, Changsha 410011, China;Identification of the two subtypes of latent autoimmune diabetes in adults by glutamic acid decarboxylase 65 antibody titers[J];中华内科杂志;2003-01
2 Wang Jianmin, Zhou Zhiguang, Wen Jianxin, et al (Institute of Metabolism and Endocrinology, Hunan Medical University, Changsha 410011);Radioligand assay of 65kD glutamic acid decarboxylase autoantibodies(GAD Ab)[J];中国糖尿病杂志;1997-02
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