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《Medical Recapitulate》 2017-02
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Research Progress in Survival Mechanism of Brucella in the Host Cells

CHEN Zhenli;ZHENG Yuanqiang;SHI Yanchun;Research Center of Molecular Biology,Inner Mongolia Medical University;  
Brucella is a facultative intracellular bacterium. Brucellosis,caused by the infection,is a serious zoonosis and results in animal abortion,sterility and local lesions of various tissues. Brucella cannot produce exotoxins,is absent of plasmids or spore forming. Although lack of these typical pathogenic factors,Brucella have strong invasion force,and strong survival and reproduction ability in the host cells. The target parasitic cells of Brucella mainly include macrophages,placental trophoblastic cells,dendritic cells,etc. Therefore,the research of the intracellular survival and replication mechanism of Brucella can provide important clues for the study of pathogenesis of brucelosis.
【Fund】: 国家“十二五”科技支撑计划项目(2014BAI13B03);; 国家自然科学基金(81660272 81460248 81260457);; 内蒙古自治区科技重大专项;; 内蒙古自治区自然科学基金(2012MS1121 2013MS1138 2015MS0820);; 内蒙古自治区科技计划项目(20120101 20120402 20110501);; 内蒙古自治区卫计委医疗卫生科研计划项目(201301035 2010018);; 内蒙古自治区高等学校科学研究项目(NJZY109)
【CateGory Index】: R516.7
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