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《Medical Recapitulate》 2017-02
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Research Progress of Disorderly Expressed Long Noncoding RNAs in Gastric Cancer

LI Zhouxiao;DONG Chaoxi;YANG Weijun;SHI Xuesong;MA Ning;CAO Hongyong;Department of General Surgery,Nanjing First Hospital,Nanjing Medical University;  
Long noncoding RNAs( lncRNAs) play essential roles in diverse biological processes,such as development,cellular differentiation,and a wide range of diseases including cancer. Recent studies have discovered that lncRNAs can participate in almost every step in the life cycle of gene regulation,including chromosome dosage compensation,imprinting,epigenetic regulation,nuclear and cytoplasmic trafficking,transcription,mRNA splicing,and translation,mainly in the four archetypes-signals,decoys,guides,and scaffolds. Multiple lncRNAs are dysregulated in gastric cancer( GC),and are closely associated with the genesis,metastasis and prognosis of cancer. Acting as biomarkers,lncRNAs have a potential clinical value for the early diagnosis,prognosis prediction and even guiding the treatment of GC.
【Fund】: 南京市医学科技发展重点项目(320.2710)
【CateGory Index】: R735.2
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