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《Medical Recapitulate》 2017-02
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Efficacy of Oxycodone Hydrochloride Sustained-release Tablets Combined with Pregabalin Treatment for Diabetic Neuropathic Pain Patients and the Influence on Protein Kinase C Activity in Plasma

FENG Hui;WANG Yulin;MO Yunda;Department of Pain Medicine,Liuzhou Worker's Hospital;  
Objective To investigate the curative effect of oxycodone hydrochloride sustained-release tablets combined with pregabalin on diabetic neuropathic pain patients and the influence on protein kinase C activity in plasma. Methods A total of 74 diabetic patients with neuropathic pain admitted to Liuzhou Worker' s Hospital from Jan. to Jun. 2015 were divided into a control group and a research group according to the random number method,37 cases each. The control group was treated with pregabalin( 75 mg,2 times / d),and the research group was treated with pregabalin( 75 mg,2 times / d) plus oxycodone hydrochloride prolonged-release tablets( 10 mg,2 times / d). The pain levels,pain relief,plasma protein kinase C activity and adverse reaction of the two groups were compared. Results At 14,21,28 days after treatment,the degree of pain in the two groups showed a downward trend. The pain relief in the study group was better than that in the control group after 21,28 days of treatment. The differences between the two groups,at different time points,between groups · different time points were statistically significant( P 0. 05). The rate of pain relief in the research group was significantly higher than that in the control group[94. 59%( 35 /37) vs 70. 27%( 26 /37) ]( P 0. 05). The plasma protein kinase C activity was significantly decreased after treatment in the two groups( P 0. 05).The level of plasma protein kinase C activity was significantly lower in the research group than that in the control group[( 13. 8 ± 4. 7) pmol/( mg·min) vs( 16. 0 ± 5. 2) pmol/( mg·min) ]( P 0. 05). Conclusion Oxycodone hydrochloride sustained-release tablets combined with pregabalin in the treatment of diabetic neuropathic pain is safe and effective,and can reduce the plasma protein kinase C activity.
【CateGory Index】: R587.2;R747.9
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