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《Medical Recapitulate》 2017-02
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Effect of Sulodexide Combined with Dipyridamole Treatment in Arteriovenous Fistula after Surgery for Chronic Renal Failure Patients with Diabetes

XUE Xiaoxia;XUE Dongxia;LIU Jian;Department of Nephrology,NO.215 Hospital of Shaanxi Nuclear Industry;Department of Hemodialysis Room,Hancheng People's Hospital;Department of Hepatobiliary Surgery,NO.215 Hospital of Shaanxi Nuclear Industry;  
Objective To probe into the effect of sulodexide combined with dipyridamole treatment in arteriovenous fistula after surgery for chronic renal failure patients with diabetes. Methods From Jan. to Dec. 2013,96 chronic renal failure patients with diabetes with arteriovenous fistula after surgery at first time were selected in NO. 215 Hospital of Shaanxi Nuclear Industry. Random number method was used to divide the patients into a study group and a control group,48 cases in each group. The control group was treated with dipyridamole orally,25 mg / time,3 times / d,maintenance therapy for30 d. Based on the control group,the study group was treated with intravenous infusion of 2 m L sulodexide injection added into 0. 9% Na Cl injection,1 time / d,maintenance therapy for 30 d. The clinical effects of the two groups were compared and analyzed. Results The overall incidence of arteriovenous fistula thrombosis after 4 weeks of the study group was lower than the control group [4. 17%( 2 /48) vs 16. 67%( 8 /48) ]( P 0. 05). The level of serum creatinine,blood urea nitrogen,24 h urinary protein of the study group after treatment were lower than those of the control group[( 254 ± 48) μmol / L vs( 293 ± 50) μmol/L,( 7. 4 ± 1. 8) mmol/L vs( 8. 9 ± 2. 0) mmol/L,( 0. 72 ± 0. 25) g vs( 1. 41 ± 0. 42) g]( P 0. 01).The fibrinogen,D- dimer of the study group were lower than the control group [( 3. 4 ± 0. 8) g / L vs( 5. 1 ± 1. 1) g / L,( 1. 0 ± 0. 2) mg/L vs( 1. 5 ± 0. 4) mg/L],the prothrombin time and activated partial thromboplastin APTT time of the study group were longer than those of the control group[( 12. 8 ± 1. 4) s vs( 10. 8 ± 1. 3) s,( 38 ± 5) s vs( 33 ± 4) s]( P 0. 01). The incidence of adverse reactions of the two groups had no statistically significant difference( P 0. 05).Conclusion Sulodexide combined with dipyridamole have definite clinical effect,less adverse reactions for treatment in arteriovenous fistula after surgery for chronic renal failure patients with diabetes.
【CateGory Index】: R692.5;R587.1
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