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《Medical Recapitulate》 2017-02
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Effect of Propofol Intravenous Anesthesia on Blood Rheology of Elderly Patients Undergoing Abdominal Operation

YU Jin;Department of Anesthesiology,PLA 273 Hospital;  
Objective To investigate the effect of propofol intravenous anesthesia on blood rheology and hemodynamics of elderly patients with abdominal surgery. Methods A total of 100 elderly patients undergoing abdominal surgery in PLA273 hospital from Aug. 2010 to Aug. 2014 were included in the stuy,then divided into an observation group and a control group according to the random number method,50 cases each. Both groups received midazolam alprazolam( 0. 1 mg / kg) +fentanyl( 0. 004 mg / kg) + atracurium( 0. 1 mg / kg) for anesthesia induction,and the observation group was continued pumping 4 mg /( kg·h) of propofol for anesthesia,while the control group inhaled sevoflurane for anesthesia( concentration2%-5%). The hemorheological indexes and blood pressure and heart rate at the time of induction of anesthesia( T_0),before tracheal intubation( T_1),immediate after cutting skin( T_2),the end of operation( T_3) of the two groups were compared,and the postoperative general conditions and adverse reactions of the two groups were compared. Results With the operation going on,the whole blood shear viscosity( high,mid and low),plasma viscosity,erythrocyte aggregation index,erythrocyte deformation index showed downward tredn,and the decreased ranges of the observation group were greater than the control group. The above indexes between groups,time points and group·time points were statistically significantly different( P 0. 05). The systolic pressure and diastolic blood pressure were decreased at first and then gradually recovered to the initiate,and the control group had bigger fluctuation range than the observation group,the heart rates of the two groups constantly fluctuated in the operation process,but both within the normal range. The blood pressures and heart rates between groups,time points and group time points were statistically significantly different( P 0. 05). The flap eyes open time,removal of intubation time,leaving observation room time and the adverse reactions incidence of the observation group were less or lower than those of the control group[( 6. 4 ± 0. 4) min vs( 13. 5 ± 2. 5) min,( 12. 4 ± 3. 3) min vs( 19. 7 ± 3. 4)min,( 23. 3 ± 5. 7) min vs( 34. 5 ± 5. 6) min,6. 0%( 3 /50) vs 24. 0%( 12 /50) ]( P 0. 05). Conclusion For the elderly patients who need abdominal surgery,the sevoflurane inhalation anesthesia,propofol intravenous anesthesia has less impact on hemorheology and hemodynamics,rapid recovery and lower incidence of adverse reactions,which is worth of the clinical promotion.
【CateGory Index】: R614
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