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Influence of hyperbaric oxygen on serum estrogen level in patients with Alzheimer's disease

WANG Huilin1,TANG Jianmei2 (1.Department of Neurology,the Second People's Hospital Huaihua General Hospital,Hu'nan Province,Huaihua 418000,China;2.Department of Hyperbaric Oxygen,the Second People's Hospital Huaihua General Hospital,Hu'nan Province,Huaihua 418000,China)  
Objective: To investigate the influence of hyperbaric oxygen(HBO) on serum estrogen(estrogen for short,E) level in patients with Alzheimer's disease(AD),thus reveal the possible mechanisms that HBO treats AD.Methods: 36 cases of female patients with AD aging from 50-80 years old,from May 2007 to May 2010 were selected.And they were divided into routine treatment group and HBO plus routine therapy group.Then each patient's intelligence and E level were detected before and after the treatment.In addition,15 women with normal intelligence in the same period and age group were choosed as control group,and the E level in each of them was also detected.Results: Improvement rate of intelligence in the HBO plus routine therapy group was higher than that in the routine therapy group,and the E level in the HBO plus routine therapy group rised after the treatment in comparison with that before the treatment,which both showed significant difference(P0.05).Conclusion: HBO has the function on treatting AD,which is probably relevant to raise the E level in the patients with AD.
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