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《Herald of Medicine》 2011-11
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Effect of Flos Lonicerae Extracts on Herpes Simplex Keratitis

LIU Ying,WANG Guo-li(Department of Biochemistry and Molecular Biology,School of Basical Medicine,China Medical University,Shenyang 110001,China)  
Objective To study therapeutic efficacy of Flos Lonicerae extracts on herpes simplex keratitis. Methods A model of Vero cells infected with herpes simplex virus-Ⅰ(HSV-Ⅰ) was established.The in vitro anti-virus effect of different doses of Flos Lonicerae extracts was evaluated by using cytopathic effect(CPE) and therapeutic index(TI).In vivo model of rabbit corner keratitis induced with herpes simplex(HSK) were established.Rabbits were treated with Flos Lonicerae extracts,Acyclovir(ACV) and normal saline for 15 days,respectively.The rabbit cornea was checked after dyeing with flourescein-natrium under slitlamp. Results It was showed that the Flos Lonicerae extracts possessed distinct anti-HSV-Ⅰ effect on Vero cells,TC0 of which was 384 mg·L-1and TI was 26.56.Compared with the model group in vivo,both Flos Lonicerae extracts and ACV significantly reduced severity of HSV-Ⅰdendritic keratitis,shortened healing time of HSK.There was no statistical significance between Flos Lonicerae extracts and ACV(P0.05). Conclusion Flos Lonicerae extracts are effective against HSK.
【CateGory Index】: R285.5
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