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《Herald of Medicine》 2017-12
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Efficacy and Safety of Combined Therapy with ~(89)Sr in Skeletal-Related Events of Prostate Cancer:A Meta-analysis

LI Liangliang;REN Xiaoqiang;XU Ziran;XIN Shiyong;ZHANG Jianguo;Department of Urology,the First Affiliated Hospital,Henan University of Science and Technoloy;College of Clinical Medicine,Henan University of Science and Technoloy;  
Objective To evaluate the efficacy and safety of combined therapy with ~(89)Sr for treating skeletal-related events of prostate cancer.Methods Databases including Pub Med,MEDLINE,EMBASE,the Cochrane library,CNKI,CBM and Wanfang were systematically searched since ~(89)Sr was first reported in 1976 to September 2015 to include the randomized controlled trials(RCTs) of the combined therapy with~(89)Sr for skeletal-related events of prostate cancer.The statistical analysis was performed using Review Manager Version 5.2.Results A total of 18 RCTs involving 1 280 patients were analyzed.The results of meta-analysis indicated:there were statistically significant differences in the pain relief rate [OR=4.71,95% CI(3.34,6.62),P0.000 1],decrement rate of bone metastasis [OR=3.63,95%CI(2.60,5.09),P0.000 1]and improvement rate of life quality [OR=2.16,95% CI(1.16,4.02),P 0.05].Progression-free survival of patients in experimental group was significantly longer than that in control group [HR=0.84,95% CI(0.73,0.97),P=0.02].No significant difference was found in overall survival [HR=0.82,95% CI(0.65,1.02),P=0.07].There were no significant differences in the incidence of adverse events[OR= 1.46,95%CI(0.98,2.17),P0.05].Conclusion Combined therapy with~(89)Sr has better efficacy and comparable safety profile compared with standard therapy.However,the quality and sample size of the included studies are limited,so more highquality and large-sample RCTs are needed to verify the validity.
【CateGory Index】: R737.25
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