Efficacy of 30% Verteporfin Photodynamic Therapy Combined with Spironolactone on Chronic Central Serous Choroidal Retinopathy
CHEN Wei;GAO Jing;ZHU Hui;LIU Shiliang;CHEN Jianbin;Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology;
Objective To compare with efficacy of 30% verteporfin photodynamic therapy( PDT) combined with spironolactone vs.the half dose verteporfin PDT on chronic central serous retinopathy( CSC). Methods A total of 27 cases of chronic CSC were randomly divided into two groups: treatment group,13 cases with 15 eyes treated by oral spironolactone combined with 30% verteporfin PDT; control group,14 patients with 17 eyes treated by 50% verteporfin PDT. In about 2 months and 6 months after PDT treatment,eyes were detected by optical coherence tomography( OCT) imaging and best corrected visual acuity( BCVA) was determined. Statistical comparison was performed in BCVA,central macular thickness( CMT),subfoveal choroidal thickness( SFCT),subretinal fluid( SRF) absorptionand the recurrence rate between the two groups at the corresponding time point. Results The comparison of BCVA,CMT,SFCT and SRF absorption and recurrence rates at all time points between the two groups showed no statistically significant differences( P 0. 05). The subretinal fluid absorption in treatment group and control group were 12 eyes and 15 eyes,respectively.The difference was statistically significant( P0.01) when BCVA,CMT and SFCT were compared with baseline 6 months after treatment in each group.The changes of BCVA in treatment group were greater than those in control group,indicating faster visual improvement. Conclusion Spironolactone combined with 30% vitipofen photodynamic therapy and half dose verteporfin photodynamic therapy for chronic CSC has similar good effect.
【CateGory Index】： R774.1