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《China Pharmaceuticals》 2002-01
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Preparation and Standardization of domestic Minocycline Hydrochloride reference substance

Gao Yanxia 1 ,Zhang Zhefeng 1 ,Zhang Jing 1 ,Zhu Jianping 1 ,Lu Yi 1 ,Ma Enqing 2 (1.The Institute for Drug Control of HeBei Province,Shijiazhuang,Hebei,China 050011;2.Department of Pharmacy,The Central Hospital of Ca  
Introduce the preparation of domestic minocycline hydrochloride reference substance and parallel analyza tion with USP minocycline hydrochloride Referen ce Substance(RS).They were showed to be identical in c onstituent,every target conformed to USPⅩⅩⅢ.Thus,by using USP RS as the standard,the content of the first lot of domestic minocycline hydrochloride refe rence substance was assayed by HPLC.The in fluence of pH of the mobile phase on re solution factor of minocycline and r elated sub-stances was also investigated.
【CateGory Index】: R95
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