The effect of Xiexin Soup of Pinellia tuber on rat' s gastric ulcer and small intestinal function
Xu Jingfeng,Wang Jinping, Xu Xi (Clinical Institute of Materia Medical, General Hospital of Military Area Command of Beijing, Beijing, China 100700) (Pharmacy Speciality 98 Trainee, Bethune Army's medical college, Shijiazhuang, Hebei, China 350001)
30min after administration of capsule of Xiexin Soup of Pinellia tuber, rats were subjected to sodden stress method to induce gastric ulcer, the incidence of the gastric ulcer obviously reduced; For rats subjected to acetic acid method to induce gastric ulcer, 11d continuous adminstration of capsule of Xiexin Soup of Pinellia tuber obviously reduce its area of ulcer. The extract of capsule of Xiesin Soup of Pinellia tuber was given subcutaneously, the remaining rate of methyl orange in stomach of mouse is reduced after 3d, it prove that the Xiexin soup of Pinellia tuber can increase gastric emptying of the mouse. After 3h ligation of combination part of pylorus and duodenum, the drug was poured into the duodenum, collect gastric juice after 3h for analyse, secretion, acidity and enzyme activity of gastric juice was not obviously influenced. The pushing experiment of the mouse s small intestine contents indicate, the capsule of Xiexin Soup of Pinellia tuber can improve the pushing rate of small intestine greatly , but has not obviously effect on the volume of intestines. After rats were planted cotton ball subcutaneously, the administration of capsule of Xiexin Soup of Pinellia tuber can reduce the weight index of granuloma induced by cotton ball.