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Sibutramine treat 78 cases of obesity

Pang Jiugao,Liu Yunqi , Liu Jun , Yan Zhongde (Department of endocrine . the Second Affiliated Hospital of Chongqing University of Medical Sciences. Chongqing 100010)  
Object: Investigate the change of serum leptin , insulin(INS), fat of blood(TG, TC, HDL - C, LDL -C), ALT, AST. body mass index (BMI), WHR, weight, heart rate, blood pressure in the persons who reduce weight before and after taking Sibutramine. to evaluate the clinical effect of the drug. Method: 78 cases of obesity or overweight. 26 cases of male, 52 cases of female, grouped in random and double - blind, take Sibutramine for 24 weeks. Leptin and INS were assayed by RIA, fat of blood were assayed by emzyme method. Other indexs were determined by common method. Result: After treatment, compare to control. BMI. weight and WHR of therapeutical group have significant difference( P0. 01). For therapeutical group. before and after treatment. Leptin. INS, fat of blood, weight. BMI. heart rate, waistline and WHR also have significant difference( P0. 01). but blood pressure and FBG have no significant difference( P0. 05). After treatment, correlation of leptin and BMI was significant. (r = 0. 611, P0. 01). correlation of waistline and INS was also significant ( r = 0. 405, P0. 01). ALT and AST increased within normal range. Conclusion: The effect of Sibutramine to reduce weight was significant. Sibutramine also has some effect on reducing leptin. INS and fat of blood, but liver ailment patients take cautiously.
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