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《China Pharmaceuticals》 2004-01
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Influence of Levofloxacin on Pharmacokinetics of Doxophylline in Rats

Li Duolu. Kan Quancheng (Medical School of Zhengzhou University, Zhengzhou. Henan. China 450052; The First Affiliated Hospital of Zhengzhou University, Zhengzhou. Henan. China 450052)  
Objective: To study the pharmacokinetics of doxophylline(Dox) combined with levofloxacin(LVFX) in rats. Methods: The Dox concentration in plasma was delected by high performance capillary electrophoresis(HPCE) method. Results: The plasma drug concentration- time curves of Dox in rats were adequately fitted to two-compartment open model. The pharmacokinetic parameters of Dox alone and combined groups in rats were: K21 (25. 78±0. 37 )h-1 and (25.35±0.59) h1: K12 (12.00 ±2.02)h-1 and (10. 75±2. 16)h-1; K10 (0.42±0. 03)h-1 and (0. 41±0.04)h-1;t1/2α(0. 02±0. 001 )h and (0. 02 ±0. 001 )h;t1/2β (2. 43±0. 10)h and (2. 38 ±0. 10)h; Vc(1. 58±0. 38 )L/kg and (1.57±0.29)L/kg; AUC (112.39±35.05)μg·h/mL and (111. 38±28.80)μg· h/mL; CLs (0. 67±0. 16)L/h and (0.66±0.14)L/h(P 0. 05) in every group. Conclusion: LVFX had no apparent influence on pharmacokinetics of Dox in rats.
【CateGory Index】: R96
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