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《China Pharmaceuticals》 2004-04
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Clinical Obser vation of Total Glucosides of Paeony to Patients of Complicated Leukopenia with Systemic Lupus Erythematosus

Li Zhijun ,Liu Yan ,Chen Linjie ,Fan Xiaoyun ,Yang Keke(Affiliated Hospital of Bangbu Medical College,Bangbu,Anhui,Chi na233004)  
Objective:To investigate the efficacy and safety of t otal glucosides of paeony(TGP)to patients of leukopemia with systemic lupus er ythematosus(SLE).Methods:33patients of complicated leukopemia with active SLE were allocated to TGP treatment and compared with33patients selected by1t o1individual matching with active SLE.Clinical and laboratory parameters were analyzed before treatment and at12weeks of treatment.Results:12weeks after treatment,the concentration of hemoglobin,the counts of leucocytes,lymphocyt es and platelet in circulation blood weren' t significantly difference in patien ts between who had used and hadn' t used TGP.However,average level of erythroc yte sedimentation rate(ESR),positive rate of anti-dsDNA in serum,average le vel of SLE disease activity index(SLEDAI),daily dosage of prednisone and infe ction rate was lower but level of complement was higher in TGP group than in the control after treatment for12weeks.Side-effect incidence was almost same bo th groups.Conclusion:TGP is effective and safety in treatment patients of leuk opemia with SLE.In addition to these,it can decrease incidence of infection wi th SLE.
【CateGory Index】: R593.241
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