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《China Pharmaceuticals》 2005-01
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An Experimental Study of the Inhibitory Effect of Ethanol Extraction of Fibaurea recisa Pierre on Hypertrophic Scar-derived Fibroblasts

Wu Kun,Pan Qiang,Yang Jun,Ding Qiaolan (Department of Pharmacy,Hospital Affiliated to the Academy of Military Sciences,Beijing,China 100039)  
Objective:To explore the effect of ethanol extraction of Fibaurea recisa Pierre on postburn hypertrophic scar-derived fibroblasts.Methods:Hypertrophic scar-derived fibroblasts were harvested and cultured in vitro.The proliferation activity of the fibroblasts is examined by MTT method.The cellular morphology,proliferation activity and the cytotoxicity of the drug were observed after 24 hours of culture.Results:The fibroblast morphology could be altered by any concentration of the ethanol extraction.Furthermore,the cell count and the cellular proliferation activity decreased obviously with the treatment of the ethanol extraction.Conclusion:The cellular morphology and proliferation activity of postburn hypertrophic scar-derived fibroblasts could all be inhibited by ethanol extraction of Fibaurea recisa Pierre in dose-dependent pattern.
【CateGory Index】: R285
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