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《China Pharmaceuticals》 2018-01
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Effect of Yiqi Huayu Bushen Recipe for Treating Postmenopausal Women Patients with Primary Osteoporosis and Its Effect on Markers of Bone Metabolism

Xing Qiujuan;Department of Rehabilitation, Changning District Tianshan Hospital of TCM,Shanghai;  
Objective To investigate the clinical effect of Yiqi Huayu Bushen Recipe in the treatment of postmenopausal women patients with primary osteoporosis and its effect on markers of bone metabolism. Methods Totally 80 postmenopausal women patients with primary osteoporosis from January 2015 to June 2017 were selected and randomly divided into the control group and the observation group,40 cases in each group. The control group was treated with conventional Western medicine,on this basis,the observation group was treated with Yiqi Huayu Bushen Recipe. The course was 3 months. The bone mineral density( BMD), TCM symptom score, the levels of serum bone tumor markers [ alkaline phosphatase( ALP),procollagen type Ⅰ N-propeptide( PINP) and C-terminal telopeptide of type Ⅰ collagen cross-linking( S-CTX) ], serum calcium, phosphorus, creatinine, parathyroid hormone( PTH) and vitamin D_3( Vit D_3) were recorded and compared. Results After treatment,compared with the control group,the value of BMD and score of TCM syndrome in the observation group increased obviously, and the level of serum bone turnover markers decreased significantly( P 0. 05). There was no significant difference in the levels of serum calcium,phosphorus,creatinine,PTH and Vit D_3 before and after treatment in the two groups( P 0. 05).Conclusion Yiqi Huayu Bushen Recipe in the treatment of postmenopausal women patients with primary osteoporosis has good effect and safety, it can improve the value of BMD and score of TCM syndrome,reduce the markers of bone metabolism, which is worthy of clinical promotion.
【Fund】: 国家自然科学基金青年科学基金项目[81102606];; 上海市卫生和计划生育委员会科研课题面上项目[201540042];上海市卫生和计划生育委员会中医药科研专项课题[2016LP053];; 上海市自然科学基金[15ZR1441600];; 上海市长宁区卫生计生系统医学重点专科项目[16-042];; 上海市长宁区卫生和计划生育委员会科研课题[20154Y018]
【CateGory Index】: R259
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