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《China Pharmaceuticals》 2018-18
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Effect of Zhilonghuoxue Tongyu Capsules on the Expression of Inflammatory Factors in Hippocampus of Epileptic Rats Induced by Lithium-Pilocarpine

Wu Ying;Zheng Zhi;Liu Li;Zhao Lizhi;Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University;Luzhou People’s Hospital;  
Objective To investigate the effect of Zhilonghuoxue Tongyu Capsules on the behavior and the expression of TNF-α,IL-1 b in hippocampus of epileptic rats induced by lithium-pilocarpine. Methods Totally 48 healthy adult male SD rats( weight 200-250 g)were randomly divided into the control group,epilepsy group,Zhilonghuoxue Tongyu Capsules group and sodium valproate group,12 rats in each group. All the rats were given intraperitoneal injection of repeated dose once every 24 h and 3 times continuously. The seizure levels of rats were recorded every day,all rats were sacrificed one day after the last administration. The expression levels of TNF-αand IL-1 b in hippocampus were detected by ELISA. Results There was no epileptic seizure in the control group,the seizure levels of Zhilonghuoxue Tongyu Capsules group and sodium valproate group were significantly lighter than that of the epilepsy group( P 0. 01).The expression levels of TNF-α and IL-1 b in epilepsy group,Zhilonghuoxue Tongyu Capsules group and sodium valproate group were significantly higher than those in the control group( P 0. 05),and those in the epilepsy group were significantly higher than those in the Zhilonghuoxue Tongyu Capsules group and sodium valproate group( P 0. 05). Conclusion The mechanism of suppressing seizure by Zhilonghuoxue Tongyu Capsules may be related to its reduction of the experession of inflammatory factors.
【Fund】: 泸州医学院自然科学基金[西南医大科[2016] 4号]
【CateGory Index】: R285.5
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