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《China Pharmaceuticals》 2018-18
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Clinical Observation on Kangfuxin Fluid Combined with Recombinant Human Epidermal Growth Factor in the Treatment of 52 Patients with Atrophic Glossitis Induced by Vitamin B_(12) Deficiency

Qi Honglin;Cai Junqiang;Yang Hua;Liu Jianmin;Deyang Stomatology Hospital;Deyang People’s Hospital;  
Objective To obsereve the clinical effect of Kangfuxin Fluid combined with recombinant human epidermal growth factor( rh EGF) in the treatment of atrophic glossitis( AG) induced by vitamin B_(12) deficiency. Methods Totally 104 patients with AG induced by vitamin B_(12) deficiency treated in Deyang Stomatology Hospital from January 2014 to October 2017 were selected and divided into the observation group and the control group according to the random number table method,52 cases in each group. The two groups were given routine vitamin B_(12) supplementation,the patients in the control group were sprayed with rh EGF tongue,on this basis,the patients in the observation group were treated with gauze soaked with Kangfuxin Fluid,and the two groups were treated for 4 weeks.Results The cure rate and the total effective rate of the observation group were 36. 54% and 96. 15%,which were significantly higher than 15. 38% and 82. 69% of the control group( P 0. 05). After treatment,the pain index and the lesion area of tongue in the two groups were significantly less than those before treatment,and those in the observation group were significantly less than those in the control group( P 0. 05). After treatment,the levels of interleukin-6( IL-6) and C reactive protein( CRP) in the two groups were significantly lower than those before treatment,and those in the observation group were significantly lower than those in the control group( P 0. 05). The incidence rate of adverse reactions in the observation group was 9. 62%,which was similar to 5. 77% in the control group( P 0. 05). Conclusion Kangfuxin Fluid combined with rh EGF is effective in the treatment of AG induced by vitamin B_(12) deficiency,it can obviously improve the prognosis,and has fewer adverse reactions,which is worthy of clinical promotion.
【Fund】: 四川省科技厅资助项目[2015SF0257]
【CateGory Index】: R781.57
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