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《China Pharmaceuticals》 2018-18
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Clinical Observation on Omeprazole Combined with Teproone in the Prevention of Complications After Endoscopic Submucosal Dissection for Early Gastric Cancer in 65 Cases

Wang Xinzhao;Ma Lijuan;Shen Minqiang;Department of Gastroenterology,The 152nd Hospital of PLA;  
Objective To observe the clinical effect of omeprazole combined with teprarone in the prevention of complications after endoscopic submucosal dissection( ESD) for early gastric cancer. Methods Totally 130 patients with early gastric cancer undergoing ESD in the hospital from June 2015 to June 2017 were divided into the observation group and the control group by the random number table method,65 cases in each group. After ESD,the control group was treated with omeprazole,and the observation group was treated with esomeprazole combined with teprarone. The two groups were treated for 1 week. Results The scores of abdominal pain in the two groups were significantly decreased on the 3 rd and 5 th postoperative day( P 0. 05),and the ulcer area in the two groups was reduced significantly( P 0. 05),and those in the observation group were significantly better than those in the control group( P 0. 05). There was no significant difference in the stage of ulcer between the two groups on the 7 th postoperative day( P 0. 05),while there was a significant difference in the stage of ulcer between the two groups on the 14 th postoperative day( P 0. 05). The ulcer healing level in the observation group was significantly higher than that in the control group( P 0. 05). The incidence rate of gastrointestinal bleeding in the two groups was similar( 1. 54% vs. 4. 61%,P 0. 05). Both of the incidence rate of adverse drug reactions in the two groups were 1. 54%( P 0. 05). Conclusion Omeprazole combined with tepritone can relieve symptoms of abdominal pain,accelerate the ulcer wound healing and reduce complications after EDS in patients with early gastric cancer.
【Fund】: 北京医卫健康公益基金会医学科学研究基金资助项目[YWJKJJHKYJJ-A105]
【CateGory Index】: R735.2
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