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《China Pharmaceuticals》 2018-18
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Analgesic and Sedative Effect of Dexmedetomidin Combined with Sufentanil on Children with Craniocerebral Injury and Its Mechanism

Sun Xiaohong;Department of Operating Room,Qinghai Women's and Children's Hospital;  
Objective To observe the analgesic and sedative effect of dexmedetomidin combined with sufentanil on children with craniocerebral injury and its mechanism. Methods Totally 64 children with craniocerebral injury admitted to our hospital from March 2014 to October 2016 were selected and divided into the observation group and the control group by the random number table method,32 cases in each group. The observation group was given dexmedetomidine combined with sufentanil,while the control group was given midazolam combined with morphine. All patients were treated with patient-controlled intravenous analgesia( PCIA) by disposable electronic analgesia pump after operation. After 6,12,18 and 24 h of treatment,the Ramsay and VAS scores of children patients were monitored. The concentrations of plasma adrenaline and noradrenaline were measured by ELISA and their effects were analyzed. Results After 6,12,18 and 24 h of treatment,the scores of Ramsay and VAS in the o bservation group were significantly lower the those in the control group( P 0. 05). After 12,18,24 h of treatment,the indexes of adrenaline and noradrenaline in the observation group were better than those in the control group( P 0. 05). The incidence rate of adverse reactions in the observation group was 12. 51%,which was significantly lower than 37. 50% in the control group( χ~2 = 5. 333,P = 0. 021 0. 05). Conclusion Dexmedetomidine combined with sufentanil has excellent analgesic and sedative effect on children with craniocerebral injury. It can effectively reduce the level of serum catecholamine,reduce the influence of vital signs and shorten the recovery time,and reduce the incidence rate of adverse reactions,which is worthy of clinical promotion.
【Fund】: 青海省科技项目[2014-SF-128]
【CateGory Index】: R726.1
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