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《China Pharmaceuticals》 2018-18
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Effect of Diammonium Glycyrrhizinate in the Adjuvant Treatment of Bronchial Asthma and Its Effect on Lung Function,Airway Inflammation and Immune Function

Han Meiyu;Han Zhiyuan;The Second People’s Hospital of Dongying;  
Objective To investigate the clincial effect of diammonium glycyrrhizinate in the adjuvant treatment of bronchial asthma( BA) and its effect on lung function,inflammatory factors and cellular immune function. Methods Totally 105 patients with BA were divided into the observation group( 53 cases) and the control group( 52 cases) by the random number table method. The patients in the control group were treated with budesonide inhalation,on this basis,the patients in the observation group were additionally treated with Diammonium Glycyrrhizinate Capsules. The two groups were treated for 4 weeks. Results The total effective rate of the observation group was 92. 45%,which was significantly higher than 78. 85% of the control group( P 0. 05). After treatment,the forced expiratory volume in 1 second( FEV_1),ratio of FEV_1 in predicted value( FEV_1%),FEV_1/forced vital capacity( FVC),macrophages,levels of CD4+,CD4+/CD8+in the observation group were significantly higher than those in the control group,while the levels of eosinophils,serum C reactive protein( CRP),interleukin-4( IL-4) and tumor necrosis factor-α( TNF-α) in the observation group were significantly lower than those in the control group( P 0. 05). No obvious adverse reactions occurred in the two groups during treatment. Conclusion Diammonium Glycyrrhizinate is effective in the adjuvant treatment of bronchial asthma,it can significantly inhibit airway inflammation and improve immune function and lung function.
【CateGory Index】: R562.25
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