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《China Pharmaceuticals》 2018-18
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Clinical Observation on Xuebijing Injection Combined with Ulinastatin in the Treatment of 53 Elderly Patients with Severe Infection

Miu Yabing;Ling Rui;Qin Long;People’s Hospital of Shanghai Pudong New District;  
Objective To observe the clinical effect of Xuebijing Injection combined with ulinastatin in the treatment of elderly patients with severe infection. Methods Totally 105 elderly patients with severe infections in ICU from March 2015 to May 2017 were divided into the observation group( n = 53) and the control group( n = 52) by the stratified randomization method. The patients in the two groups were treated with Xuebijing Injection,on this basis,the patients in the observation group were treated with Ulinastatin,they were treated with 14 d continuously. Results After treatment,the levels of WBC,PCT and CRP in the two groups were significantly decreased,and the decrease in the observation group was more significant( P 0. 05). The levels of IL-6 and TNF-α in the two groups were significantly decreased than those before treatment,while the levels of IL-10 in the two groups were significantly increased than those before treatment,and the change in the observation group was more significant( P 0. 05). The average hospitalization time and APACHE Ⅱ score in the observation group were significantly decreased than those in the control group( P 0. 05). The total effective rate of the observation group was 94. 34%,which was significantly higher than 80. 77% of the control group( P 0. 05). The mortality rate of the observation group was 3. 92%,which was significantly lower than 15. 38% of the control group( P 0. 05). Conclusion Xuebijing Injection combined with ulinastatin in the treatment of elderly patients with severe infections has significant clinical effect,it can effectively reduce the levels of inflammatory factors,reduce mortality rate,which has significant clinical value.
【CateGory Index】: R459.7
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