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《China Pharmaceuticals》 2018-18
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Comparative Effects Between Irbesartan and Hydrochlorothiazide Tablets and Benazepril Hydrochloride Tablets in the Treatment of Patients with Hypertension and Hyperlipidemia

Wen Rujun;Cao Jianfeng;Luo Yuxin;Liang Ladi;Shenzhen Longhua People’s Hospital;  
Objective To compare the effects between Irbesartan and Hydrochlorothiazide Tablets and Benazepril Hydrochloride Tablets on blood pressure variability,blood lipid metabolism indexes and electrocardiogram of patients with hypertension and hyperlipidemia.Methods Totally 149 patients with hypertension and hyperlipidemia admitted to our hospital were selected and randomly divided into the observation group( n = 69) and the control group( n = 80) by the stratified randomization method. The observation group was treated with Irbesartan and Hydrochlorothiazide Tablets,while the control group was treated with Benazepril Hydrochloride Tablets. The two groups were treated for 2 weeks. Results The total effective rate of the observation group was 92. 75%,which was not significantly different from 85. 00% of the control group( P 0. 05),but the level of curative effect in the observation group was significantly better than that in the control group( P 0. 05). After treatment,the decrease of 24 h systolic blood pressure and diastolic blood pressure standard deviation( 24 h SBPV,24 h DBPV),daytime systolic and diastolic blood pressure standard deviation( DSBPV,DDBPV),nighttime systolic blood pressure and diastolic blood pressure standard deviation( NSBPV,NDBPV) in the observation group was more obvious than that in the control group,the levels of serum total cholesterol( TC),triglyceride( TG) and low-density lipoprotein cholesterol( LDL-C)in the observation group were decreased,which were lower than those in the control group,while high-density lipoprotein cholesterol( HDL-C) level,QT interval and QRS axis in the observation group were increased,which were higher than those in the control group,the differences were statistically significant( P 0. 05). There was no significant statistical difference in the incidence rate of adverse reactions between the two groups( 5. 80% vs. 6. 25%,P 0. 05). Conclusion Compared with Benazepril Hydrochloride Tablets,Irbesartan and Hydrochlorothiazide Tablets can better improve the blood pressure variability,blood lipid metabolism indexes and electrocardiogram of patients with hypertension and hyperlipidemia,but there was no significant difference in safety between the two drugs.
【CateGory Index】: R544.1;R589.2
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