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Expression of Vasoactive Intestinal Peptide In Lichen Planus Lesions

ZHOU Yan,XI Yan-ping,ZHENG Yan, et al (Department of Dermatology,The Second Hospital,Xi’an Jiaotong University,Xi’an 710004,China)  
Objective To investigate the function of vasoactive intestinal peptide(VIP) in pathogenesis of LP.Methods The expression of VIP in lesion specimens from 20 patients with LP and normal skin from 20 healthy volunteers were examined with immunohistochemistry.Positive staining in lesions was distributed in the whole epidermis,brown-yellowish staining was observed in cell plasma,while positive staining in normal skin was localized mainly at the basal cell layer.Results Compared with the normal skin,the positive rate and the mean expression level of VIP in lesions of LP were significantly higher,( P 0.05).Conclusion The higher level of VIP in the lesions of patients with LP may play a patial role in the pathogenesis of LP.
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