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Detection of CD44v6 in Chronic Vulvar Dystrophy,Vaginal Intraepithelial Neoplasia(VIN) and Vulvar Carcinoma

LIU Ming,QU Qun,ZONG Lu, et al (Departmemt Gynecology and Obstrophy,Second Hospital of Xi,an Jiao Tong University 710004,China)  
Objective To discuss the relationship between CD44v6 and genesis,development and metastasis of vulvar squamous carcanoma.Methods To detect CD44v6 in chronic vulvar dystrophy,VIN and vulvar carcinoma by immunohistochemical method S-P.Results No CD44v6 in normal epithelium.The positive rates of CD44v6 in chronic vulvar dystrophy,VIN and vulvar squamous carcinoma were 26.7%,53.3% and 73.3%.It had positive correlation with clinical stage of vulvar squamous carcinoma,The positive rate of CD44v6 in people with lymph nodes metastasis as 92.3% was higher than that of those without lymph nodes metastasis( P 0.05).Conclusion CD44v6 has close relationship with lymphnodes metastasis.
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