Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《The Chinese Journal of Dermatovenereology》 2013-01
Add to Favorite Get Latest Update

Expression of Cx43 and C-myc and their Significance in Skin Pathological Scar Epithelium

GUO Rui-zhen1, WANG Juan2, ZHOU Kai-mei3 (1. Department of Pathology, Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China; 2. Department of Pathology, Jiangsu Huaiyin Advanced Vocationl﹠Technical School of Health,Huai’an 223001,China; 3. Department of Pathology, the First People’s Hospital of Yibin Sichuan, Yibin 644000, China)  
Objective To explore the significance of Cx43 and C-myc protein expression in skin pathological scar epithelium. Methods Four cancer gene, four tumor suppressor gene and one apoptosis gene were detected in normal skin, skin pathological scar tissues and skin scar carcinoma tissues using immunohistochemical method of SP and in situ hybridization method. Combined with image analysis,pairwise comparisons of statistical significance of Cx43 and C-myc were reported. Results The expressions of Cx43 and Cx43 mRNA in skin scar carcinoma, skin pathological scar epithelium and normal skin epidermis were lowered gradually, there were statistically different between each of two groups (P0.05). C-myc protein showed strong positive,positive and negative expression in scar carcinoma tissues,skin pathological scar epithelium and normal skin epidermis respectively. There were statistically different between each of two groups(P0.05). Conclusion Compared with normal skin group,the low expression of Cx43 and the high expression of C-myc proteins in the skin pathological scar epithelium tissues may be related to the scar carcinogenesis.
【Fund】: 贵州省攻关项目(2010-3080)
【CateGory Index】: R622
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 WANG Juan,GUO Rui-zhen.(Department of Pathology,Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China);Current Study of Skin Scar Carcinoma and GJIC[J];Medical Recapitulate;2008-11
2 GUO Rui-zhen,ZHOU Kai-mei,WU Xiao-mei(Pathology Department of Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China);Expression and Significance of CyclinA,p21~(WAF1) and C-myc in Skin Scar and Skin Scar Carcinoma[J];The Chinese Journal of Dermatovenereology;2011-05
3 GUO Rui-zhen1,WANG Juan1,CHEN Shi-jiu2,TANG Wen-tai3,WU Xiao-mei21. Department of Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China; 2. No.5 Affiliated Hospital of Zunyi Medical College;3. Pathology Department of No.1 Affiliated Hospital of Zunyi Medical College;Expressions of Cx43,Survivin,PTEN in Skin Scar and Skin Scar Carcinoma[J];Cancer Research on Prevention and Treatment;2010-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHOU Kai-mei1,GUO Rui-zhen1,CHEN Shi-jiu2(1Department of Pathology,Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China;2No 5 Affiliated Hospital of Zunyi Medical College,Zhuhai 519100,China);Expressions and significance of cyclin-A and p21~(WAF1) in skin scar and skin scar carcinoma[J];Chinese Journal of Clinical and Experimental Pathology;2011-07
2 WANG Jing-qiong,MENG Dan Department of Pathology,Medical College of Ningbo University,NingBo 315211,China.;Research on the relationship between the C-myc and non-Hodgkin,s lymphoma[J];Journal of Modern Oncology;2010-12
3 TANG Zhao-hui,ZHOU Lu-ting,XIE Zhi-fang,YANG Jia-mei,HU Yi-ping,ZHANG Wei-ping,WU Meng-chao. Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200433,China;Expressions of c-myc,ZHX2,and alpha fetoprotein genes in hepatic regenerate tissue of mice after partial hepatectomy[J];The Journal of Practical Medicine;2009-11
4 GUO Rui-zhen,ZHOU Kai-mei,WU Xiao-mei(Pathology Department of Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China);Expression and Significance of CyclinA,p21~(WAF1) and C-myc in Skin Scar and Skin Scar Carcinoma[J];The Chinese Journal of Dermatovenereology;2011-05
5 GUO Rui-zhen,LI Na,JIN Jun-feng(Pathology Department of Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China);The Expression of Cx32 mRNA and Genetic Mutation in the Pathological Scar and Scar Carcinoma and Protein Detection of Skin[J];The Chinese Journal of Dermatovenereology;2012-02
6 GUO Rui-zhen1,WANG Juan1,CHEN Shi-jiu2,TANG Wen-tai3,WU Xiao-mei21. Department of Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China; 2. No.5 Affiliated Hospital of Zunyi Medical College;3. Pathology Department of No.1 Affiliated Hospital of Zunyi Medical College;Expressions of Cx43,Survivin,PTEN in Skin Scar and Skin Scar Carcinoma[J];Cancer Research on Prevention and Treatment;2010-01
7 GUO Rui-zhen1,ZHOU Kai-mei1,Wang Yan2 1.Department of Pathology,Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China,2.Department of Molecula Biology;Expressions and Significance of CyclinA and C-myc in Skin Scar and Skin Scar Carcinoma[J];Cancer Research on Prevention and Treatment;2011-10
8 LI Na,GUO Rui-zhen Department of Pathology,Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China;Significance of Cx26 Gene Expressions and Mutation in Skin Scar and Skin Scar Squamous Cell Carcinoma[J];Cancer Research on Prevention and Treatment;2011-12
9 GUO Ruizhen1,TANG Wentai2,DU Jinfeng1 (1.Department of Pathology,Zhuhai Campus of Zunyi Medical College,Zhuhai,Guangdong 519041,P.R.China; 2.Department of Pathology,No.1 Affiliated Hospital of Zunyi Medical College,Zunyi,Guizhou 563003,P.R.China);Expressions of Cx43 and Cx43mRNA in skin basal cell carcinoma and skin squamous cell carcinoma[J];China Journal of Modern Medicine;2009-22
10 Wang qiuhong1,Bian ke1,Zhang susu1,Guo ruizhen2,Wang haiqing2 (1.Department of Clinical Medicine,Zhuhai Campus of Zunyi Medical College,Guangdong Zhuhai 519041,China;2.Department of Pathology,Zhuhai Campus of Zunyi Medical College,Guangdong Zhuhai 519041,China);Study on the correlation between Cx43 protein expression and metastasis of different types of tumor[J];Acta Academiae Medicinae Zunyi;2012-06
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Fan Song -Qing 1 ,Zhou Ming 1 ,Xiang Qiu 1 ,Wang Jie-Ru 1 ,Xiong Wei 1 ,Wang Rong 1 ,Wei Qi-You 2 ,Zhou Jin-Ping 2 ,Li Gui-Yuan 11.Cancer Research Institute,Xiangya Medical College,University of Central South China,Changsha,Hunan,410078,P.R.China2.Department of Pathology,The Second Xiangya Hospital,Universit y of Central South China,Changsha,Hunan,410011,P.R.China;In Situ Expression of Connexins in Va rious Carcinomas[J];Chinese Journal of Cancer;2003-07
2 CAO Yu-Wen1, LU Tian-Cai1, PAN Xiao-Lin1, LI Feng1, ZHONG Hao-Hao2, SUN Yan1, JIANG Jin-Fang1, LI Li11. MOE Laboratory of Xinjiang Endemic and Ethnic Disease/Department of Pathology, School of Medicine, Shihezi University, Shihezi, Xinjiang, 832002, P.R.China2. Department of Pathology, Health Science Center, Peking University, Beijing, 100083, P.R.China;Correlation of Expression of Connexin to Growth and Progression of Cervical Carcinoma In Situ[J];Chinese Journal of Cancer;2005-05
3 ;Expressions of c-myc and bcl-2 in primary hepatocellular carcinoma and their clinical values[J];Acta Academiae Medicinae Militaris Tertiae;2003-09
4 HUANG Jin, LIN Ju-Sheng, DONG Xu-Yang, CHANG Ying, SONG Yu-HuInstitute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Construction of siRNA eukaryotic expression vectors of PEG10 gene and their apoptosis-inducing effect on transfected HepG2 cells[J];Journal of the Fourth Military Medical University;2007-03
5 CHEN Jie.Wuhan Third Hospital,Wuhan 430060,China;Expression of telomerase reverse transcriptase and c-myc oncogene in lung cancer[J];Journal of Clinical Internal Medicine;2003-11
6 Guo Ruizhen,Liang Guozhen,He Miaoxia,et al(Zunyi Medical college,Zunyi 563003);A Study of Association Between Midline T cell Lymphoma and Epstein Barr Virus[J];THE PRACTICAL JOURNAL OF CANCER;1998-02
7 Hai-Tao Ren,Heng-Shu ZhangHai-Tao Ren,Heng-Shu Zhang,Department of Cosmetic Surgery,the First Affiliat ed Hospital of Chongqing University of Medical Sciences,Chongqing 400016,China;Expression of Survivin in scar tissue and its clinical significance[J];Chinese Journal of Clinical Rehabilitation;2004-11
8 WANG Juan,GUO Rui-zhen.(Department of Pathology,Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China);Current Study of Skin Scar Carcinoma and GJIC[J];Medical Recapitulate;2008-11
9 SHI Guo-guang;Clinical Analysis on 9 Cases of Scar Carcinoma[J];The Chinese Journal of Dermatovenereology;2006-01
10 ZHAO Ping-wei,HUANG Xian-li,JIANG Yan-fang.Department of Hepatobiliary Surgery, Fourth Hospital,Jilin University,Changchun 130011,China;Research on C-MYC oncogene amplification in the tissue of liver cancer and liver cirrhosis[J];Chinese Medicine of Factory and Mine;2005-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved