Correlational Analysis between the CD4~+T Cell Counts and Opportunistic Infection in HIV / AIDS Patients with No Antiretroviral Treatment
LI Shi-fu;GAO Liang-min;CAI Ying;FU Jin-cui;ZHU Yong-fen;XU Jie;LI Zai-you;ZHAO Jin-xian;STD and AIDS Department,Yuxi Centre for Disease Control and Prevention;Research Center for Public Health,School of Medicine,Tsinghua University;
Objective To explore the correlation of the natural CD4~+T cell and the incidence of opportunistic infections( OIs) during a year of HIV/AIDS patients with no antiretroviral treatment so as to supervise the OIs treatment. Methods We collected 739 cases of newly reported HIV / AIDS,and the data of OIs incidence in a year and the counts of CD4~+,CD8~+T cell were collected through 4 times regular follow-up. The difference between the base line and the last CD4~+,CD8~+T cell counts was calculated and described. Results The total 207 cases( 28. 01%) of the 739 HIV / AIDS patients experienced HIV related OIs within the past year,the incidence of OIs of the people aged 50 or more and those less than 50 were 79. 69% and 23. 11%respectively( P 0. 05). With decreased baseline of CD4~+T cell counts,the incidence of OIs were raised from 8. 97% to 69. 02%( P 0. 05). The value of CD4~+,CD8~+T cell counts and CD4 / CD8 ratios in the patients with OIs were lower than those without OIs( P 0. 05). The ration of patients with significant and slow deletions of CD4~+T cell counts incurring HIV related OIs was 48. 72% and 25. 18%,while the patients with slow and significant increase of CD4~+T cell counts incurring HIV related OIs were 18. 45%and 9. 01%. There is statistical significance between two groups( P 0. 05). Conclusion The low counts of CD4~+T cell might suggest higher risk of developing OIs,and the significant deletions of CD4~+T cell counts corresponds to the possibility of HIV related OIs risk. Dynamic detection of the counts and the changes related to the natural CD4~+T cell will be of great help for the prediction and prevention of OIs in patients with HIV / AIDS.
【CateGory Index】： R512.91