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《The Chinese Journal of Dermatovenereology》 2017-05
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Th17/Treg Balance in Peripheral Blood of Patients with Alopecia Areata

WANG Hong-feng;GAN Hui-hui;MEI Li-hong;YANG Gao;FANG Fang;Department of Dermatology Jinshan Affiliated Hospital of Fudan University;  
Objective To determine the status of Th17/Treg balance in peripheral blood of patients with alopecia areata( AA) and whether it is affected by co-existent autoimmune diseases. Methods The proportion of Th17 and Treg cells in CD4~+T cells was analyzed with flow cytometry in AA and healthy controls. Results In comparison with healthy controls,the frequencies of Th17 cells were significantly higher in AA patients,with the highest in severe AA or AA accompanied by autoimmune diseases. In contrast,AA patients exhibited low frequencies of Treg cells,particularly in severe AA or AA with autoimmune diseases. The ratio of Th17/Treg was notably higher in patients with AA than in the controls. Conclusion Th17/Treg imbalance exists in AA patients,especially in severe AA or AA patients with other autoimmune diseases. Autoimmune diseases may worsen the imbalance of Th17/Treg,leading to progression of AA.
【Fund】: 上海市金山区科委资助项目(2013-3-12)
【CateGory Index】: R758.71
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Bo,YANG Shu-xia (Department of Dermatovenereology,the First Hospital of Peking University,Beijing 100034,China);Cytokine profiles in alopecia areata[J];临床皮肤科杂志;2011-06
2 WANG Lin,GAO Lin,WANG Hua(Institute of Dermatology of Chinese PLA,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China);CD4~+,CD25~+ Regulatory T Cell,and T Lymphocyte Subgroups Detection on Peripheral Blood Lymphocyte and Its' Significance in the Patients with Alopecia Areata[J];中国皮肤性病学杂志;2008-11
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Hong-feng;GAN Hui-hui;MEI Li-hong;YANG Gao;FANG Fang;Department of Dermatology Jinshan Affiliated Hospital of Fudan University;;Th17/Treg Balance in Peripheral Blood of Patients with Alopecia Areata[J];中国皮肤性病学杂志;2017-05
2 JIANG Qiong;ZHANG Rong;MENG Yang;Department of Dermatology,The Third People's Hospital of Bengbu;;Effect of the compound glycyrrhizin combined with minoxidil and desonide in the treatment of alopecia areata[J];蚌埠医学院学报;2016-05
3 WANG Yao;SUN Xiao-yan;Department of Traditional Chinese Medicine,The People's Hospital of Daxing District;Department of Dermatology,The People's Hospital of Daxing District;;Effect of Plum-blossom Needle combined with oral decoction on blood parameters and related molecules expressed in hair follicle of patients with alopecia areata[J];临床和实验医学杂志;2015-12
4 ;Change of T Cell Subset in Alopecia Areata Patients with Liver and Kidney Deficiency Type[J];湖北中医杂志;2015-02
5 KANG Xiao-ping;LONG Fei;XUE Qin;ZHANG Peng;Department of Dermatology, Wuhan Number 7 Hospital;Tianyou Hospital Affiliated to Wuhan University of Science & Technology;;Serological indexes and peripheral blood immune index detection in patients with alopecia areata and its correlation with hair loss area[J];海南医学院学报;2015-01
6 Liu Xiaojing;Xu Feng;Han Yumei;Sheng Youyu;Miao Ying;Hu Ruiming;Guo Xia;Qi Sisi;Yang Qinping;Department of Dermatology,Huashan Hospital,Fudan University;;Detection of T helper type 17 cells in peripheral blood of patients with alopecia areata[J];中华皮肤科杂志;2014-11
7 ZHANG Guo-ping;HUANG Zhuang-feng;DONG Jia-hui;HUANG Xiao-xiong;Huizhou Dermatology Hospital;;Clinical observation of BozhiPian combined with compound glycyrrhizin and plum-blossom needle for the treatment of the mild alopecia areata[J];中国美容医学;2014-13
8 CHEN Xiuyang;LIANG Jiafen;LI Hongyi;CHEN Dacan;LUO Jiasheng;Dept. of Dermatology, the Second Affiliated Hospital, Guangzhou University of Chinese Medicine;;Effect of Yifa Oral Liquid and Wufa Tincture on Immune Function of Alopecia Areata patients with Liver and Kidney Deficiency Syndrome[J];广州中医药大学学报;2014-02
9 FANG Xiu-ping;WANG Wan-juan;JIN Chan;LI Chao-hong;LI Ping;Department of Dermatology,Hong Hui Hospital,Xi-an Jiaotong University College;Department of Dermatology,The Second Affiliated Hospital,Xi-an Jiaotong University College;The Second Affiliated Hospital,Xi-an Medical College;;Sleep Quality and Related Factors in 136 Cases of Alopecia Areata[J];中国皮肤性病学杂志;2014-03
10 YANG Su;YANG Xiao;LI Min;Department of Dermatology,Nanjing Children’s Hospital of Nanjing Medical University;;Measurement of serum levels of 25-Hydroxyvitamin D in children with alopecia areata[J];中华全科医学;2014-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
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