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《The Chinese Journal of Dermatovenereology》 2017-05
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Th17/Treg Balance in Peripheral Blood of Patients with Alopecia Areata

WANG Hong-feng;GAN Hui-hui;MEI Li-hong;YANG Gao;FANG Fang;Department of Dermatology Jinshan Affiliated Hospital of Fudan University;  
Objective To determine the status of Th17/Treg balance in peripheral blood of patients with alopecia areata( AA) and whether it is affected by co-existent autoimmune diseases. Methods The proportion of Th17 and Treg cells in CD4~+T cells was analyzed with flow cytometry in AA and healthy controls. Results In comparison with healthy controls,the frequencies of Th17 cells were significantly higher in AA patients,with the highest in severe AA or AA accompanied by autoimmune diseases. In contrast,AA patients exhibited low frequencies of Treg cells,particularly in severe AA or AA with autoimmune diseases. The ratio of Th17/Treg was notably higher in patients with AA than in the controls. Conclusion Th17/Treg imbalance exists in AA patients,especially in severe AA or AA patients with other autoimmune diseases. Autoimmune diseases may worsen the imbalance of Th17/Treg,leading to progression of AA.
【Fund】: 上海市金山区科委资助项目(2013-3-12)
【CateGory Index】: R758.71
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Chinese Journal Full-text Database 10 Hits
1 WANG Hong-feng;GAN Hui-hui;MEI Li-hong;YANG Gao;FANG Fang;Department of Dermatology Jinshan Affiliated Hospital of Fudan University;;Th17/Treg Balance in Peripheral Blood of Patients with Alopecia Areata[J];中国皮肤性病学杂志;2017-05
2 JIANG Qiong;ZHANG Rong;MENG Yang;Department of Dermatology,The Third People's Hospital of Bengbu;;Effect of the compound glycyrrhizin combined with minoxidil and desonide in the treatment of alopecia areata[J];蚌埠医学院学报;2016-05
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