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《The Chinese Journal of Dermatovenereology》 2017-05
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Clinico-Histopathological Analysis of 78 Out Patients with Leprosy at Department of Dermatology at A General Hospital

LI Ling-jia;ZHANG Sheng;LIU Tong-yun;XIE Yu-yan;CHAI Yan-jie;DONG Tian-xiang;Department of Dermatologist,the First Affiliated Hospital of Kunming Medical University;Department of Clinical Laboratory,Yan'an Hospital Affiliated to Kunming Medical University;  
Objective To investigate the clinicopathological features of leprosy,in order for dermatologists to improve the diagnosis. Methods Clinical and pathological data were retrospectively analyzed in 78 outpatients with leprosy from January 2008 to July 2016. Results Clinical manifestations of leprosy included circumscribed or diffuse infiltrative hypopigmented macules,plaques and nodules in annular to irregular shapes,and ulceration. Sometimes leprosy was accompanied by loss of eyebrow,thickened ear and/or ulnar nerves,and fever. Lesions mainly located on the face,neck,trunk and limbs. Clinical classification: TT accounted for20. 51%( 16/78),BT 2. 56%( 2/78),BB 5. 13%( 4/78),BL 14. 10%( 11/78),LL 17. 95%( 14/78),and in determinate leprosy( I) 1. 28%( 1/78). 39. 74% of patients( 31/78) couldn't be classified based on clinical pathology. Histological features included infiltration of inflammatory or foam cells around blood vessels,nerves and cutaneous appendix. Lesions involved the upper and middle dermis in 53. 85%( 42/78cases). Destruction of basal layer presented in 93. 59%( 73/78). Epidermal atrophy and grenz zone occurred in 55. 13%( 43/78) and 46. 15%( 36/78),respectively. 47. 44%( 37/78) were positive for Acidfast staining. Only 15. 38%( 12/78) completed tissue fluid smears. Conclusion The clinical manifestations of leprosy varied. Specific histopathological features together with Acid-fast staining can dramatically improve the diagnosis of leprosy and reduce misdiagnosis rates.
【CateGory Index】: R755
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 CUI Deng-feng(Center for Disease Control and Prevention of Qingyang in Gansu Province,Qingyang 745000,China);One Cases of Lepromatous Leprosy Misdiagnosed of Systemic Lupus Erythematosus(SLE)[J];中国皮肤性病学杂志;2012-03
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 HUANG He;REN Jun;ZHANG Jianling;WANG Shizhen;Department of Dermatology,the Second People's Hospital of Bijie;;A Recurrent Case of Lepromatous Leprosy after MDT Treatment Misdiagnosed as Lichen Planus[J];中国皮肤性病学杂志;2018-01
2 YANG Ying;CHEN Xiao-hong;YANG Ying;YUAN Wei;ZHENG Ting-ming;Department of Dermatology,Affiliated Hospital of Medical College Zunyi;;Tow Cases of Leprosy and Literature Review[J];中国皮肤性病学杂志;2017-10
3 LI Ling-jia;ZHANG Sheng;LIU Tong-yun;XIE Yu-yan;CHAI Yan-jie;DONG Tian-xiang;Department of Dermatologist,the First Affiliated Hospital of Kunming Medical University;Department of Clinical Laboratory,Yan'an Hospital Affiliated to Kunming Medical University;;Clinico-Histopathological Analysis of 78 Out Patients with Leprosy at Department of Dermatology at A General Hospital[J];中国皮肤性病学杂志;2017-05
4 CHEN Peng;YUAN Wei;Department of Dermatology and Venereology,the Affiliated Hospital of Zunyi Medical University;;A Case of Lepromatous Leprosy[J];中国皮肤性病学杂志;2015-01
5 HU Ke(The Disease Control and Prevention Center of Liucheng County,Liucheng,Guangxi Zhuang Nationality Autonomous Region 545200,China);Study of a 5-Year Misdiagnosis Case of Lepromatous Leprosy[J];临床误诊误治;2013-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 YUAN Hua-gang(Department of Dermatology,Tongnan County People's Hospital,Tongnan 402660,China);Two Cases of Misdiagnoses of Leprosy[J];中国皮肤性病学杂志;2011-06
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