Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《The Chinese Journal of Dermatovenereology》 2017-05
Add to Favorite Get Latest Update

Effects of Intermittent Application of Immunomodulators on Peripheral Blood Lymphocytes in Patients with Subclinical Genital Herpes

ZHANG Jing;XING Qian-qian;YANG Feng-yuan;MENG Jian;JIANG Dong-xiang;CHENG Pei-hua;Department of Dermatology,Affiliated Hospital of Guilin Medical University;Laboratory,Affiliated Hospital of Guilin Medical University;  
Objective This study was to investigate the factors affecting immune status in patients with subclinical genital herpes,and the improvements in immune status after treatment with immunomodulators. Methods HSV viral carriers were identified using fluorescent quantitative polymerase chain reaction( q PCR). Flow cytometry was used to evaluate the patients' immune function. Percentages of peripheral blood lymphocytes were compared in HSV~+vs. HSV-,more( annual recurrence ≥6) vs. less( annual recurrence 6) frequent recurrence,as well as before and after immunomodulator therapy. Results Lower percentages of CD3~+,CD4~+,CD4~+/CD8~+T cells were found in HSV~+group( P 0. 05 vs. HSV-). Patients with more frequent recurrence showed significantly lower percentages of CD3~+,CD4~+,CD4~+/CD8~+,natural killer cells,and higher percentage of CD8~+T cells( P 0. 05 vs. annual recurrence 6). Patients in the treatment group displayed significantly lower percentages of CD3~+,CD4~+,CD4~+/CD8~+,natural killer cells,and higher percentage of CD8~+T cells in comparison with normal controls( P 0. 05). Following the treatment,the proportions of CD3~+,CD4~+,CD4~+/CD8~+,natural killer cells increased while the proportion of CD8~+T cells decreased( P 0. 05 vs. pre-treatment). There were no significant differences in B cells in all groups( P 0. 05). Conclusion Patients with subclinical genital herpes exhibit compromised immunity. Patients with HSV~+or more frequent recurrence display severe immunosuppression. Treatment with combination of immunomodulators can improve immune function in HSV~+patients.
【Fund】: 广西桂林市科技局攻关项目(2013012010);; 广西自然科学基金(2013GXNSFAA019206)
【CateGory Index】: R752.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 5 Hits
1 MO Xiang1,WEI You-ming2.(1.Department of Clinical Laboratroy,2.Department of Dermatology,Nanning First People′s Hospital,the Nanning First People′s Hospital,Nanning 530022,China);Research Progress of Immune Cell Function in Patients with Recurrent Genital Herpes[J];医学综述;2012-15
2 LI Hui,WANG Yong-jun,SUN Jin (School of Pharmacy,Shenyang Pharmaceutical University of Pharmacy,Shenyang 110016,China);Progress of pidotimod and its preparation[J];中国药剂学杂志(网络版);2012-04
3 WU Jian1,JIA Guo-quan1,WU Rui-bin2,CHEN Yong-jing3,XU Ping1,WU Min-zhi1,ZHANG Xue-guang3(1.The Fifth People Hospital of Suzhou,Suzhou 215007,China; 2.The Skin Disease Hospital of Wuzhong District,Suzhou 215007,China; 3.School of Life Science of Suzhou University,Suzhou 215007,China);T Cell Subsets and Costimulatory Molecule in Peripheral Blood of Patients with Recurrence Genital Herpes[J];中国皮肤性病学杂志;2010-12
4 Lin Lan and Liu Jianwen(National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050);Advance in Research on the Thymosin Preparation[J];中国药事;2009-07
5 LIU Ruo-ying, GUO Zhou-ke, YANG Shu-dong, YANG Yu-feng, YANG Xu-yun, DING Na-na Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033, China;Research on the Relation between Depression Symptom of Patients with Recrudescent Genital Herpes and Cellular Immunity[J];中国中西医结合皮肤性病学杂志;2006-01
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 Sun Yaoran;Qing Yingying;Guo Kan;Gao Qingwei;School of Chemical Engineering, Shijiazhuang University;;Research on the synthetic process of L-thiazolidine-4-formic acid ethyl ester hydrochloride[J];煤炭与化工;2017-12
2 YANG Li;NIU Yan-yan;CHANG Ying;LIU Yang;ZHANG Mei-fang;Department of Dermatology,Shaanxi Provincial People's Hospital;Department of Dermatology,Suqian First Hospital;Pharmaceutical Preparation Section,Shaanxi Maternal and Child Care Service Centre;Department of Center Laboratory,Shaanxi Provincial People's Hospital;;The Pathogenic Significance of Changes in CCR4 Expression on Tregs Cells in Recurrent Genital Herpes[J];中国皮肤性病学杂志;2017-12
3 QIU Xinfeng;Dept.of Pharmacy,Anqing Hospital Affiliated to Anhui Medical University;;Content Determination of Thymosin α_1 in Thymopolypeptides Enteric-coated Tablets by HPLC-MS/MS[J];中国药房;2017-30
4 ZHOU Rui-qi;LIU Jie;LIU Hui;HANG Tai-jun;China Pharmaceutical University;Hainan Provincial Institute for Drug and Food Control;;Identification of the Related Substances of Pidotimod by LC/MS[J];质谱学报;2017-04
5 ZHANG Jing;XING Qian-qian;YANG Feng-yuan;MENG Jian;JIANG Dong-xiang;CHENG Pei-hua;Department of Dermatology,Affiliated Hospital of Guilin Medical University;Laboratory,Affiliated Hospital of Guilin Medical University;;Effects of Intermittent Application of Immunomodulators on Peripheral Blood Lymphocytes in Patients with Subclinical Genital Herpes[J];中国皮肤性病学杂志;2017-05
6 Yuan Cailian;Department of Dermatology,NO.2 Affiliated Hospital of Guangdong Medical College;;Therapeutic Effect of Valacyclovir,Thymosin Combined with Jieyu God on Herpes Zoster[J];数理医药学杂志;2017-04
7 HU Xiao-lei;YUAN Hai-yan;Department of Pharmacy, the First Affiliated Hospital of Third Military Medical University;Department of Pharmacy, Second Xiangya Hospital, Central South University;Institute of Clinical Pharmacy, Second Xiangya Hospital, Central South University;;Progress on clinical research of pidotimod[J];中南药学;2017-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ;匹多莫德口服与雾化吸入对反复呼吸道感染的疗效比较[J];当代医学;2011-25
2 WU Jian1,JIA Guo-quan1,WU Rui-bin2,CHEN Yong-jing3,XU Ping1,WU Min-zhi1,ZHANG Xue-guang3(1.The Fifth People Hospital of Suzhou,Suzhou 215007,China; 2.The Skin Disease Hospital of Wuzhong District,Suzhou 215007,China; 3.School of Life Science of Suzhou University,Suzhou 215007,China);T Cell Subsets and Costimulatory Molecule in Peripheral Blood of Patients with Recurrence Genital Herpes[J];中国皮肤性病学杂志;2010-12
3 Chen Qian,Liu Dong(Department of Pharmacy of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030,China);Pharmacokinetics and Bioequivalence of Pidotimod Syrup in Healthy Volunteers[J];中国药师;2010-12
4 ;复发性生殖器疱疹患者血清细胞因子的表达及机体细胞免疫功能的研究[J];内蒙古中医药;2010-15
5 CHEN Yong-feng, CHANG Shu-xia, WANG Xiao-hua (Guangdong Province Centre for Skin Diseases and STIs Control and Prevention,Guangzhou 510500,China);Study on the Serum Level of Interleukin 13 and Interleukin 15 in Patients with Recurrent Genital Herpes[J];皮肤性病诊疗学杂志;2010-02
6 LIU Wei,CHEN Jing,XIONG Ting(Dept. of Pharmacy,Zhongnan Hospital of Wuhan University,Wuhan 430071,China);Bioequivalence of Pidotimod Granules and Pidotimod Syrup in Healthy Volunteers[J];中国药房;2009-20
7 XING Cai-mei,LI Zhen-hua,WU Yi(Futian Traditional Chinese Medicine Hospital,Shenzhen 518048,Guangdong,P.R.China);Role of HSV Ⅱ antigen-specific CD8~+ cytotoxic T cells in pahogenesis of patients with genital herpes by pentamer technology[J];中国热带医学;2009-06
8 DONG Hai-jun,GAO Shu,ZHAO Ming-xia,ZHANG Jun-dong,ZHU Xia-li(Hefei Con-source Medicine Technology Corporation,Hefei 230088,China)LI Jian-chun(Dept. of Pharmacy,Bengbu Medical College,Bengbu 233030,China);Pharmacokinetics and Bioequivalence of Pidotimod Dried-Suspension in Healthy Volunteers[J];中国药房;2008-35
9 GUO Cai-e1, LI Wei-hong2, XIONG Nan-yan3 (1.Integrative Traditional and Western Medicine Hospital, Handan, Hebei 056001, P.R.China; 2. Handan County Hospital, Handan, Hebei 560000, P.R.China; 3.Medical College of Hebei Engineering University, Handan, Hebei 056029, P.R.China);Medical analysis of 64 cases thymosin prevention of bronchial asthma[J];中国现代医学杂志;2008-19
10 SHEN Wei (Mudu People’s Hospital,Suzhou,Jiangsu,215101);Efficacy of Thymosin Combined with Chemotherapy in Non-small Cell Lung Cancer[J];中国血液流变学杂志;2008-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved