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Effects oh Huangqi (Astragalus membranaceus) and DES on Skeleton of Ovariectomized Rats

Li Chaoyang; Wu Tie; Huang Lianfang et al. (Bone Biology Laboratory, Guangdong Medical College,Zhanjiang, 524023)  
SD rats n-32, 3-month-old,were randomly divided in groups of basal control,aging control,ovariectomiaed (OVX), OVX+DES (Diethylstilbestrol ) 5 mL/kg·d (4. 5mg/L) and OVX+Astragalus membranaceus 5mL/kg. d(1kg/L)ig, 6 times a week. After 12 weeks,their proximal tibiae were processed to undecalcified sections at 20 μm thickness for histomorphometric analysis. Results:trabecullar bone mass in the OVX group reduced markedly(%Tb. Ar-68%) due to bone turnover increase with bone resorption exceeded bone formation. Treatment with Huangqi and DES increased significantly the bone mass (%Tb. Ar+122%and+85% respectively) as compared with OVX control. The orotective effects of the two drugs appeared to be quite similar but the mechanism involved may be different. Huangqi suppresses principally bone resorption while DES inhibits bone resorption as well as bone formation. Conclusion:Results of the study showed that Huangqi and DES could prevent trabecular loss in OVX rats.
【Fund】: 国家自然科学研究基金!39470367
【CateGory Index】: R285
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