Studies on the Chemical Constituents of Hemsley Melodinus (Melodinus hemsleyanus)
Yan Kexu and Feng Xiaozhang (Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Xiehe Medical University, Beijing 100050)
10 compounds were isolated from Melodinus hemsleyanus Diels. and their structures were determined by spectral analysis and chemical reactions. They were 11-hydroxytabersonine (Ⅰ), scandine (Ⅱ), 10-hydroxyscandine(Ⅲ), tubotaiwine(Ⅳ), tubotaiwine N-oxide(Ⅴ), 15α-hydroxykopsinine(Ⅵ),vincoline(Ⅶ), 19R-vindolinine N-oxide(Ⅷ), 16 β-hydroxy-19R-vindolinine (Ⅸ) and a new compound, 16β-hydroxy-19S-vindoline N-oxide(Ⅹ). Pharmacological screening revealed that Ⅰ had antitumor activety.