Protective Effect of Chaihu Injection on Hypoxia-reoxygenation-induced Mouse Liver Injury
Tang Bing; Wu Yiren and Kang Gefei (Department of Hygiene Toxicology, Chongqing University of Medical Sciences, Chongqing 400016)
By using isolated mouse liver perfusion model, the protective effect of Chaihu injection on hypoxia-reoxygenation liver injury was studied. The activity of lactate dehydrogenase (LDH) in perfusion liquid, the activity of xanthine oxidase (XOD), the content of glutathione (GSH) and malondialdehyde (MDA) in liver homogenate were investigated at different time courses. Liver pathology by light microscopy and electronic microscopy were observed after perfusion. The result implied that Chaihu injection has a significant protective effect on mouse liver injury induced by hypoxia-reoxygenation perfusion. The mechanism of action may be related to its inhibitory effect on the formation of free radicals.